816430-02-1

Basic information

• Product Name: Ethyl 2-(tert-butoxycarbonylamino)-3-cyclobutylpropanoate
• Synonyms: Ethyl 2-(tert-butoxycarbonylamino)-3-cyclobutylpropanoate;Cyclobutanepropanoic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-, ethyl ester
• CAS NO: 816430-02-1
• Molecular Formula: C₁₄H₂₅NO₄
• Molecular Weight: 271.3526
• Mol File: 816430-02-1.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethyl 2-(tert-butoxycarbonylamino)-3-cyclobutylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-(tert-butoxycarbonylamino)-3-cyclobutylpropanoate(816430-02-1)
• EPA Substance Registry System: Ethyl 2-(tert-butoxycarbonylamino)-3-cyclobutylpropanoate(816430-02-1)

Safety Data

• Hazardous Substances Data: 816430-02-1(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(tert-butoxycarbonylamino)-3-cyclobutylpropanoate is a chemical compound with the molecular formula C14H25NO4. It is commonly used as a reagent in organic synthesis and pharmaceutical research. Ethyl 2-(tert-butoxycarbonylamino)-3-cyclobutylpropanoate is a derivative of propanoic acid and contains a cyclobutyl group and a tert-butoxycarbonyl-protected amino group. It is a colorless liquid with a mild, fruity odor and is soluble in organic solvents such as ethanol and diethyl ether. Ethyl 2-(tert-butoxycarbonylamino)-3-cyclobutylpropanoate is commonly used in the production of pharmaceuticals and as a building block in the synthesis of complex organic molecules.

Upstream product

• 394735-17-2 ethyl 2-amino-3-cyclobutylpropanoate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1025799-39-6 2-(benzhydrylidene-amino)-3-cyclobutyl-propionic acid ethyl ester 
• 17247-58-4 (Bromomethyl)cyclobutane 
• 565456-74-8 C₉H₁₇NO₂*ClH 

Downstream Products

• 816429-99-9 SCH 503034D 
• 394735-25-2 {(S)-2-[(1R,2S,5S)-2-(2-Carbamoyl-1-cyclobutylmethyl-2-hydroxy-ethylcarbamoyl)-6,6-dimethyl-3-aza-bicyclo[3.1.0]hex-3-yl]-1-cyclohexyl-2-oxo-ethyl}-carbamic acid tert-butyl ester 
• 394735-28-5 (1R,2S,5S)-N-(4-amino-1-cyclobutyl-3-hydroxy-4-oxobutan-2-yl)-3-((S)-2-(3-(tert-butyl)ureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-3-azabicylo[3.1.0]-hexane-2-carboxamide 
• 1036931-36-8 3-amino-4-cyclobutyl-2-hydroxybutanamide hydrochloride 
• 394735-22-9 tert-butyl 4-amino-1-cyclobutyl-3-hydroxy-4-oxobutan-2-ylcarbamate 
• 394730-60-0 boceprevir 
• 394735-18-3 tert-butyl 3-cyclobutyl-1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate 
• 394735-20-7 (2-cyano-1-cyclobutylmethyl-2-hydroxyethyl)carbamic acid tert-butyl ester 
• 394735-19-4 (2-cyclobutyl-1-formylethyl)carbamic acid tert-butyl ester 
• 565456-75-9 2-(tert-butoxycarbonylamino)-3-cyclobutylpropanoic acid 

Relevant articles and documents

PROCESS FOR PREPARATION OF BOCEPREVIR AND INTERMEDIATES THEREOF

THE PRESENT INVENTION RELATES TO AN IMPROVED PROCESS FOR THE PREPARATION OF (1R,5S)-N-[3-AMINO-1-(CYCLOBUTYLMETHYL)-2,3-DIOXOPROPYL]-3-[2(S)-[[[(1,1-DIMETHYLETHYL)AMINO]CARBONYL] AMINO]-3,3-DIMETHYL-1-OXOBUTYL]-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEXAN-2(S)-CARBOXAMIDE AND ITS INTERMEDIATES

Pharmaceutical formulations and methods of treatment using the same

Pharmaceutical formulations containing at least one compound of Formulae I-XXVI herein and at least one surfactant. Pharmaceutically acceptable carriers and excipients may also be included in the formulations. The formulations of the present invention are suited for use in single unit dosages.

Methods of treating hepatitis C virus

Methods for preventing, ameliorating or treating one or more symptoms of Hepatitis C virus (HCV), modulating HCV protease activity and/or inhibiting cathepsin activity in a subject, wherein the methods comprise administering to a subject in need of such treatment a dosage formulation containing at least one compound of Formulae I-XXVI herein, wherein the dosage formulation is capable of maintaining an average Cmin plasma concentration of the compound at or above 10 ng/ml.