81684-02-8Relevant articles and documents
NMR Spectra and Stereochemistry of 1,5- and 1,6-Disubstituted Perhydrooxazolo pyridines
Crabb, Trevor A.,Trethewey, Andrew N.
, p. 299 - 302 (1989)
13C and 1H NMR spectroscopy showed that with the exception of r-1,t-6,t-8a-1-alkyl-6-ethylperhydrooxazolo pyridines (alkyl= ethyl, isopropyl) which adopt the O-inside cis-fused conformation, all the other 1-alkyl-6-ethyl- and 1-alkyl-cis(H-5,H-8a)-5-methyl-perhydrooxazolo pyridines adopt trans-fused conformations (CDCl3, 298 K). KEY WORDS Perhydrooxazolo pyridines Conformation 1H and 13C NMR
N-alkylation of lactams with secondary heterobenzylic bromides
Yu, Ming,Stevenson, Karis,Zhou, Gene
supporting information, p. 5591 - 5594 (2014/12/11)
We herein report a general N-alkylation reaction of lactams with secondary heterobenzylic bromides. This methodology features mild reaction condition, moderate to high product isolation yield, and broad substrate scope. Good chemical and structural tolerance has also been demonstrated by both the secondary heterobenzylic bromides and lactam substrates.