82010-31-9

Basic information

• Product Name: BOC-L-LEUCINOL
• Synonyms: BOC-(S)-2-AMINO-4-METHYL-1-PENTANOL;BOC-LEUCINOL;BOC-LEU-OL;BOC-L-LEUCINOL;BOC-L-LEU-OL;(S)-2-(TERT-BUTYLOXYCARBONYL-AMINO)-4-METHYL-1-PENTANOL;(S)-(-)-2-(BOC-AMINO)-4-METHYL-1-PENTANOL;N-T-BOC-L-LEUCINOL
• CAS NO: 82010-31-9
• Molecular Formula: C₁₁H₂₃NO₃
• Molecular Weight: 217.31
• Product Categories: Amino Acids;Leucine [Leu, L];Amino Alcohols;Boc-Amino acid series;Amino Acid Derivatives;Amino Alcohols;Peptide Synthesis
• Mol File: 82010-31-9.mol
• Article Data: 93

Chemical Properties

• Boiling Point: 213 °C
• Flash Point: >230 °F
• Appearance: Clear colorless to pale yellow/Viscous Liquid
• Density: 0.983
• Vapor Pressure: 2.8E-05mmHg at 25°C
• Refractive Index: n20/D 1.450
• Storage Temp.: -15°C
• PKA: 12.11±0.46(Predicted)
• Sensitive: Moisture Sensitive
• BRN: 4178460
• CAS DataBase Reference: BOC-L-LEUCINOL(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-L-LEUCINOL(82010-31-9)
• EPA Substance Registry System: BOC-L-LEUCINOL(82010-31-9)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 82010-31-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H23NO3/c1-8(2)6-9(7-13)12-10(14)15-11(3,4)5/h8-9,13H,6-7H2,1-5H3,(H,12,14)/t9-/m0/s1

Upstream product

• 3392-09-4 Boc-Leu-ONSu 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 39520-24-6 Isobutylmalonsaeure-dimethylester 
• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 
• 34619-03-9 tert-butyldicarbonate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1234196-13-4 2-(tert-butoxycarbonylamino)-4-methylpentyl acetate 
• 543-27-1 isobutyl chloroformate 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 61-90-5 L-leucine 
• 2666-93-5 (S)-Leu-OMe 
• 25462-20-8 2-hydroxymethyl-4-methylpentan-1-ol 
• 913546-31-3 (S)-2-(acetyloxymethyl)-4-methylpentanoic acid 
• 14568-42-4 (S)-2-isocyanato-4-methylpentyl acetate 

Downstream Products

• 58521-45-2 tert-butoxycarbonyl-L-leucinal 
• 380228-30-8 [(2-tert-butoxycarbonylamino-4-methyl-pentyl)-(2-nitro-benzenesulfonyl)-amino]-acetic acid methyl ester 
• 832104-28-6 (S)-2-amino-4-methylpentyl 2-sulfobenzoate 
• 854402-91-8 (3S)-3-Amino-2-hydroxy-5-methyl-N-(2-phenoxyethyl)hexanamide hydrochloride 
• 3392-09-4 Boc-Leu-ONSu 
• 97920-15-5 4(S)-<<<-N^im-tosyl-L-histydyl>amino>-2,2-difluoro-6-methyl-3-oxoheptanoyl>-L-isoleucyl-2-pyridylmethylamine 
• 97920-14-4 {(S)-1-[(S)-1-[(S)-1-(2,2-Difluoro-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-acetyl)-3-methyl-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester 
• 97995-52-3 {(S)-1-[(S)-1-[(S)-1-((S)-2,2-Difluoro-1-hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester 
• 97920-12-2 <4(S)-<<-L-histidyl>amino>-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine 
• 103346-52-7 <4(S)-<im-tosyl-L-histidyl>amino>-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl>-L-isoleucyl-2-pyridylmethylamine 
• 82252-38-8 N^α-Boc-LeuΨVal-OBzl 
• 112157-33-2 (H-Leu(CH₂S)-)2*2HCl 
• 142554-62-9 (S)-(-)-1,1-dimethylethyl <3-methyl-1-<<<<<2,6-bis(1-methylethyl)phenyl>amino>carbonyl>amino>methyl>butyl>carbamate 

Relevant articles and documents

COMPOUNDS AND METHODS OF USE

Disclosed are heterocyclic compounds or their pharmaceutically acceptable salts with ferroptosis-inducing activity, Those compounds or their pharmaceutically acceptable salts can be used to treat cancer.

Thiamine hydrochloride as a recyclable organocatalyst for the efficient and chemoselective N-tert-butyloxycarbonylation of amines

Thiamin hydrochloride promoted highly efficient and ecofriendly approach has been described for the chemoselective N-tert-butyloxycarbonylation of amines under solvent-free conditions at ambient temperature. The demonstrated approach has been applicable for the N-Boc protection of variety of aliphatic, aryl, heteroaryl amines. The chemoselective protection of amino group occurs in chiral amines and amino alcohol without racemization in high yield. Thiamin hydrochloride is stable, economical, easy to handle and environmentally friendly.

Nanoceria as an efficient and green catalyst for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions

Nanocerium oxide mediated an efficient and green protocol has been described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at ambient temperature. Various aliphatic, aromatic and heteroaromatic amines were protected using developed protocol and several functional groups such as alcohol, phenol and ester were well tolerated under these conditions. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.