820961-78-2

Basic information

• Product Name: Phosphinous acid, diphenyl-, 1-methyl-3-phenylpropyl ester
• CAS NO: 820961-78-2
• Molecular Formula: C22H23OP
• Molecular Weight: 334.398
• Mol File: 820961-78-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Phosphinous acid, diphenyl-, 1-methyl-3-phenylpropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphinous acid, diphenyl-, 1-methyl-3-phenylpropyl ester(820961-78-2)
• EPA Substance Registry System: Phosphinous acid, diphenyl-, 1-methyl-3-phenylpropyl ester(820961-78-2)

Safety Data

• Hazardous Substances Data: 820961-78-2(Hazardous Substances Data)

Upstream product

• 2344-70-9 1-phenyl-3-butanol 
• 1079-66-9 chloro-diphenylphosphine 

Downstream Products

• 73475-33-9 2-methyl-4-phenylbutanenitrile 

Relevant articles and documents

Camphorquinone: A new and efficient oxidant for the preparation of 2-thio-substituted benzothiazoles from alcohols by oxidation-reduction condensation

A convenient one-pot procedure for the preparation of various 2-thio-substituted benzothiazoles from alcohols and benzothiazole-2-thiol utilizing camphorquinone-mediated oxidation-reduction condensation is disclosed. The condensation between benzothiazole-2-thiol and alkyl diphenylphosphinites, generated in situ from alcohols and chlorodiphenylphosphine, proceeded smoothly in the presence of camphorquinone to furnish the corresponding benzothiazoles in good to moderate yields.

Cyanation of alcohols with diethyl cyanophosphonate and 2,6-dimethyl-1,4-benzoquinone by a new type of oxidation-reduction condensation

Cyanation of various alcohols by a new type of oxidation-reduction condensation is described. Primary alkyl diphenylphosphinites, 2,6-dimethyl-1,4-benzoquinone (DMBQ), and diethyl cyanophosphonate gave the corresponding nitriles in high yields. During the above experiment on cyanation of 4-phenylbutan-2-ol, the unexpected formation of a mixture of nitrile and isocyanide was observed. After careful examination of the reaction conditions, selective synthesis of isocyanides from secondary alcohols was successfully accomplished by the use of zinc oxide (ZnO) as an additive. Reaction of tertiary alcohols provided the corresponding isocyanides exclusively in the absence of an additive. Cyanation of optically active alcohols was tried in order to clarify the stereochemistry of this reaction, and the reaction was thus proved to proceed with the inversion of configuration.