82121-08-2

Basic information

• Product Name: 4-HYDROXY-7-METHOXYQUINOLINE
• Synonyms: 7-METHOXYQUINOLIN-4(1H)-ONE;7-METHOXYQUINOLIN-4-OL;7-METHOXY-4(1H)-QUINOLINONE;7-Methyl-4-quinolinol;7-methylquinolin-4-ol;4-Hydroxy-7-methylquinoline AldrichCPR;7-methyl-1H-quinolin-4-one
• CAS NO: 82121-08-2
• Molecular Formula: C10H9NO2
• Molecular Weight: 175.18
• Mol File: 82121-08-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 286.4 °C at 760 mmHg
• Flash Point: 129.2 °C
• Appearance: /
• Density: 1.15 g/cm³
• CAS DataBase Reference: 4-HYDROXY-7-METHOXYQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-7-METHOXYQUINOLINE(82121-08-2)
• EPA Substance Registry System: 4-HYDROXY-7-METHOXYQUINOLINE(82121-08-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 82121-08-2(Hazardous Substances Data)

Usage

General Description

4-Hydroxy-7-methoxyquinoline, also known as cupreidine, is a chemical compound that belongs to the quinoline class of organic compounds. It is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes. 4-HYDROXY-7-METHOXYQUINOLINE has demonstrated antimicrobial and antioxidant properties, making it potentially useful in the development of new drugs and other products. It is also used as a ligand in metal-organic frameworks and as a corrosion inhibitor in metal treatment applications. Additionally, 4-hydroxy-7-methoxyquinoline has been studied for its potential anti-cancer and anti-inflammatory properties, indicating its potential as a valuable compound in pharmaceutical and medicinal research.

Upstream product

• 36053-96-0 7-methyl-2,3-dihydroquinolin-4(1H)-one 
• 41460-18-8 ethyl 4-hydroxy-7-methylquinoline-3-carboxylate 
• 19056-83-8 diethyl 2-{[(3-methylphenyl)amino]methylene}propane-1,3-dioate 
• 108-44-1 1-amino-3-methylbenzene 
• 51726-77-3 4-hydroxy-7-methylquinoline-3-carboxylic acid 
• 29027-17-6 2-chloro-3-methylaniline 
• 6291-29-8 8-chloro-4-hydroxy-7-methyl-quinoline-3-carboxylic acid ethyl ester 
• 855764-51-1 8-chloro-4-hydroxy-7-methyl-quinoline-3-carboxylic acid 
• 25063-50-7 2,2-dimethyl-5-(m-tolylamino-methylene)-[1,3]dioxane-4,6-dione 
• 855871-26-0 8-chloro-7-methyl-quinolin-4-ol 
• 71-36-3 butan-1-ol 

Downstream Products

• 63136-61-8 4-chloro-7-methyl-quinoline 
• 36053-96-0 7-methyl-2,3-dihydroquinolin-4(1H)-one 
• 50332-60-0 4-Hydroxy-7-methyl-3-nitrochinolin 
• 5408-67-3 chloroquine 

Relevant articles and documents

Nitrogen-containing heterocyclic compound as well as preparation method, pharmaceutical composition and application thereof

The invention provides a nitrogen-containing heterocyclic compound as well as a preparation method, a pharmaceutical composition and application thereof, and particularly provides a compound as shownin a formula I which is described in the specification,

Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities

A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of P. falciparum W2.

Preparation of 4-hydroxyquinolines

Process for the preparation of 4-hydroxyquinolines of the general formula: STR1 in which R represents a hydrogen atom, or one, two or three substituents, which may be the same or different, selected from halogen atoms, alkyl radicals containing 1 to 4 carbon atoms, alkoxy radicals containing 1 to 4 carbon atoms, and the trifluoromethyl radical, the substituent(s) being in the 2-, 3-, 5-, 6-, 7- or 8-position, by the oxidation, by means of oxygen or air, in the presence of a catalyst based on platinum or ruthenium, or alloys thereof, of a 1,2,3,4-tetrahydroquinolin-4-one of the general formula: STR2 in which R is as defined above.