821768-11-0

Basic information

• Product Name: Pyridine, 1,2,3,6-tetrahydro-4-(2-methylphenyl)-1-(phenylmethyl)-
• CAS NO: 821768-11-0
• Molecular Formula: C19H21N
• Molecular Weight: 263.382
• Mol File: 821768-11-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Pyridine, 1,2,3,6-tetrahydro-4-(2-methylphenyl)-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 1,2,3,6-tetrahydro-4-(2-methylphenyl)-1-(phenylmethyl)-(821768-11-0)
• EPA Substance Registry System: Pyridine, 1,2,3,6-tetrahydro-4-(2-methylphenyl)-1-(phenylmethyl)-(821768-11-0)

Safety Data

• Hazardous Substances Data: 821768-11-0(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 16419-60-6 2-Methylphenylboronic acid 
• 107301-61-1 N-benzyl-4-amino-1-butyne 
• 932-31-0 ortho-tolylmagnesium bromide 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 95-46-5 2-methylphenyl bromide 
• 83674-75-3 1-benzyl-4-o-tolylpiperidin-4-ol 

Downstream Products

• 630116-52-8 4-(2'-methylphenyl)piperidine 
• 864829-37-8 7-[4-(2-methylphenyl)piperidine-1-carbonyl]-5,6,7,8-tetrahydrocyclohepta[b]pyridine-9-one 
• 864829-88-9 tert-butyl (3R*,4R*)-3-fluoro-4-o-tolylpiperidine-1-carboxylate 
• 864829-89-0 tert-butyl (3S*,4R*)-3-fluoro-4-o-tolylpiperidine-1-carboxylate 
• 864830-75-1 (7RS)-7-(4-o-tolylpiperidin-1-ylmethyl)-5,6,7,9-tetrahydro-8H-pyrido[2,3-b]azepin-8-one 
• 82212-02-0 4-(2-methylphenyl)piperidine hydrogen chloride salt 

Relevant articles and documents

Palladium(0)-catalyzed alkynyl and allenyl iminium ion cyclizations leading to 1,4-disubstituted 1,2,3,6-tetrahydropyridines

(Chemical Equation Presented) The biologically important title heterocyclic compounds can be synthesized by two methods based on the cyclization of alkynyl and allenyl iminium ions generated in situ in the presence of organometallic reagents (see scheme).

CYCLOALKANOPYRIDINE DERIVATIVE

Provided are cycloalkanopyridine derivatives of formula [I]: [wherein the symbols are the same as those stated in the description]. The compounds act as a nociceptin receptor antagonist, and are useful as medicines for diseases associated with a nociceptin receptor, for example, as a reliever against tolerance to a narcotic analgesic; a reliever against dependence on or addiction to a narcotic analgesic; an analgesic enhancer; an antiobesitic or appetite suppressor; a treating or prophylactic agent for cognitive impairment and dementia/amnesia; an agent for treating developmental cognitive abnormality; a remedy for schizophrenia; an agent for treating neurodegenerative diseases; an anti-depressant or treating agent for affective disorder; a treating or prophylactic agent for diabetes insipidus; a treating or prophylactic agent for polyuria; or a remedy for hypotension.