822-90-2

Basic information

• Product Name: 2,4,5-trimethyl-1H-imidazole
• Synonyms: 2,4,5-trimethyl-1H-imidazole;1H-IMidazole, 2,4,5-triMethyl-
• CAS NO: 822-90-2
• Molecular Formula: C₆H₁₀N₂
• Molecular Weight: 110.157
• EINECS: 212-507-6
• Mol File: 822-90-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 163℃
• Boiling Point: 292℃
• Flash Point: 150℃
• Appearance: /
• Density: 1.003
• Vapor Pressure: 0.00332mmHg at 25°C
• Refractive Index: 1.517
• CAS DataBase Reference: 2,4,5-trimethyl-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-trimethyl-1H-imidazole(822-90-2)
• EPA Substance Registry System: 2,4,5-trimethyl-1H-imidazole(822-90-2)

Safety Data

• Hazardous Substances Data: 822-90-2(Hazardous Substances Data)

Usage

General Description

2,4,5-trimethyl-1H-imidazole is an organic compound with the chemical formula C6H9N3. It is a derivative of imidazole, which is a five-membered heterocyclic compound containing nitrogen. This chemical is commonly used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of dyes, resins, and other industrial chemicals. It can also be employed as a stabilizer for plastics and as a corrosion inhibitor for metals. In addition, 2,4,5-trimethyl-1H-imidazole has potential applications in the field of medicinal chemistry due to its ability to interact with biological systems and its potential use as a building block for drug design. Overall, this chemical compound has a variety of important industrial and pharmaceutical applications.

InChI:InChI=1/C6H10N2/c1-4-5(2)8-6(3)7-4/h1-3H3,(H,7,8)

Upstream product

• 50-00-0 formaldehyd 
• 431-03-8 dimethylglyoxal 
• 81277-92-1 N-(diethoxymethyl)-2,4,5-trimethylimidazole 
• 142-71-2 copper diacetate 
• 513-86-0 3-hydroxy-2-butanon 
• 75-07-0 acetaldehyde 
• 89356-40-1 2-(1-hydroxyiminoethyl)-2,4,5-trimethyl-2H-imidazole 1-oxide 
• 70807-89-5 2,4,5-trimethylimidazole hydrochloride 
• 20662-84-4 2,4,5-trimethyloxazole 
• 77287-34-4 formamide 

Downstream Products

• 1323403-29-7 3-(1-OXO-4-((4-((2,4,5-TRIMETHYL-1H-IMIDAZOL-1-YL) METHYL) BENZYL)OXY)ISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE FORMATE 
• 25812-77-5 1,2,3,4,5-pentamethyl-1H-imidazol-3-ium iodide 
• 1739-83-9 1,2,4,5-tetramethylimidazole 
• 139261-08-8 1-acetyl-2,4,5-trimethylimidazole 
• 68303-35-5 2-chloro-3,5,6-trimethylpyrazine 
• 24307-72-0 5-Chlor-2,4,6-trimethylpyrimidin 
• 34916-70-6 4-chloro-2,5,6-trimethylpyrimidine 

Relevant articles and documents

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Lewis Pair Polymerization of Epoxides via Zwitterionic Species as a Route to High-Molar-Mass Polyethers

A dual catalytic setup based on N-heterocyclic olefins (NHOs) and magnesium bis(hexamethyldisilazide) (Mg(HMDS)2) was used to prepare poly(propylene oxide) with a molar mass (Mn) >500 000 g mol?1, in some cases even >106 g mol?1, as determined by GPC/light scattering. This is achieved by combining the rapid polymerization characteristics of a zwitterionic, Lewis pair type mechanism with the efficient epoxide activation by the MgII species. Transfer-to-monomer, traditionally frustrating attempts at synthesizing polyethers with a high degree of polymerization, is practically removed as a limiting factor by this approach. NMR and MALDI-ToF MS experiments reveal key aspects of the proposed mechanism, whereby the polymerization is initiated via nucleophilic attack by the NHO on the activated monomer, generating a zwitterionic species. This strategy can also be extended to other epoxides, including functionalized monomers.

Phosphine Supported Ruthenium Nanoparticle Catalyzed Synthesis of Substituted Pyrazines and Imidazoles from α-Diketones

A new methodology has been developed for the synthesis of highly substituted nitrogen heterocycles such as pyrazines and imidazoles starting from α-diketones using phosphine supported ruthenium nanoparticles (RuNPs) as catalysts. Ruthenium nanoparticles Ru1-Ru4 supported with different phosphines such as dbdocphos, dppp, DPEphos, and Xantphos are screened, of which Ru1 and Ru4 are found to be the most active. Interestingly, aryl-substituted and alkyl-substituted α-diketones produced different products: namely, pyrazine and imidazoles, respectively. This reaction methodology has been applied to the synthesis of a key intermediate (2m) of the marine cytotoxic natural product Dragmacidin B and an estrogen receptor (2l). This work represents the first examples of pyrazines prepared by RuNPs.