82228-14-6Relevant articles and documents
Quinoline compound containing sulfonamide structure as well as preparation method and medical application thereof
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Paragraph 0033; 0040-0041, (2021/07/01)
The invention belongs to the technical field of medicines, and relates to a quinoline compound containing a sulfonamide structure as well as a preparation method and medical application of the quinoline compound. The quinoline compound containing the sulf
Preparation method and medical application of sulfonamide compounds with glucuronic acid structures
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Paragraph 0024, (2018/05/30)
The invention belongs to the technical field of pharmacy, and provides sulfonamide compounds with glucuronic acid structures. Structures of the sulfonamide compounds with the glucuronic acid structures are shown in a general formula (I) and a general form
A mechanistic study of the non-oxidative decarboxylation catalyzed by the radical S-adenosyl-l-methionine enzyme BlsE involved in blasticidin S biosynthesis
Liu, Lei,Ji, Xinjian,Li, Yongzhen,Ji, Wenjuan,Mo, Tianlu,Ding, Wei,Zhang, Qi
supporting information, p. 8952 - 8955 (2017/08/15)
Decarboxylation is a fundamentally important reaction in biology and involves highly diverse mechanisms. Here we report a mechanistic study of the non-oxidative decarboxylation catalyzed by BlsE, a radical S-adenosyl-l-methionine (SAM) enzyme involved in blasticidin S biosynthesis. Through a series of biochemical analysis with isotopically labeled reagents, we show that the BlsE-catalyzed reaction is initiated by the 5′-deoxyadenosyl (dAdo) radical-mediated hydrogen abstraction from a sugar carbon of the substrate cytosylglucuronic acid (CGA), and does not involve a carboxyl radical as has been proposed for 4-hydroxyphenylacetate decarboxylase (HPAD). Our study reveals that BlsE represents a mechanistically new type of radical-based decarboxylase.