82436-77-9

Basic information

• Product Name: BS3
• Synonyms: OCTANEDIOIC ACID BIS-(2,5-DIOXO-3-SULFO-PYRROLIDIN-1-YL) ESTER SODIUM SALT;BIS(SULFOSUCCINIMIDYL)SUBERATE;BIS(SULFOSUCCINIMIDYL) SUBERATE, SODIUM SALT;BSSS;BS3;suberic acid bis(3-sulfo-n-hydroxysuccinimide ester)sodium salt;BIS-SULFO-SUCCINIMIDYL SUBERATE BS3;Suberate Bis(sulfosuccinimidyl) Sodium Salt
• CAS NO: 82436-77-9
• Molecular Formula: C16H18N2Na2O14S2
• Molecular Weight: 572.43
• Product Categories: Nitric Oxide Reagents;Cross Linking Reagents;Homobifunctional Crosslinker;homoXlink
• Mol File: 82436-77-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: >300°C
• Appearance: /powder
• Density: 1.78 g/cm³
• Refractive Index: 1.627
• Storage Temp.: −20°C
• Solubility: H2O: 10 mg/mL
• PKA: -0.34±0.20(Predicted)
• CAS DataBase Reference: BS3(CAS DataBase Reference)
• NIST Chemistry Reference: BS3(82436-77-9)
• EPA Substance Registry System: BS3(82436-77-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-24/25-22
• Hazardous Substances Data: 82436-77-9(Hazardous Substances Data)

Usage

Chemical Properties

Suberate Bis(sulfosuccinimidyl) Sodium Salt is Off-White Solid

Uses

Different sources of media describe the Uses of 82436-77-9 differently. You can refer to the following data:
1. Suberate Bis(sulfosuccinimidyl) Sodium Salt is a water-soluble protein cross-linker for: cross-linking and targeting of mouse erythrocytes, receptor-ligand cross-linking, cross-linking of calveolin proteins, cross-linking of growth factors to proteinase inhibitor, and cross-linking of glass bead.
2. Suberic acid bis(3-sulfo-N-hydroxysuccinimide ester) sodium salt (BS3) is useful for the preparation of protein-protein, receptor-ligand and hapten carrier molecule conjugates.

General Description

Suberic acid bis(3-sulfo-N-hydroxysuccinimide ester) sodium salt (BS3) is a water soluble, homobifunctional cross-linking reagent with amine reactivity. It is typically coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). It incorporates 8-atom linker.

InChI:InChI=1/C16H20N2O14S2/c19-11-7-9(33(25,26)27)15(23)17(11)31-13(21)5-3-1-2-4-6-14(22)32-18-12(20)8-10(16(18)24)34(28,29)30/h9-10H,1-8H2,(H,25,26,27)(H,28,29,30)

Relevant articles and documents

DLL3-TARGETING MULTISPECIFIC ANTIGEN-BINDING MOLECULES AND USES THEREOF

The disclosure provides multispecific antigen-binding molecules that comprise a first antigen-binding moiety and a second antigen-binding moiety, each of which is capable of binding to CD3 and CD137, but does not bind to CD3 and CD137 at the same time; and a third antigen-binding moiety that is capable of binding to DLL3, preferably human DLL3, which induce T-cell dependent cytotoxity more efficiently whilst circumventing adverse toxicity concerns or side effects that other multispecific antigen-binding molecules may have. The present invention provides multispecific antigen-binding molecules and pharmaceutical compositions that can treat various cancers, especially those associated with DLL3, by comprising the antigen-binding molecule as an active ingredient.