82485-84-5

Basic information

• Product Name: (2-Chloro-4,6-dimethoxyphenyl)amine
• Synonyms: 2-CHLORO-4,6-DIMETHOXYANILINE;(2-Chloro-4,6-dimethoxyphenyl)amine;1-Amino-2-chloro-4,6-dimethoxybenzene;2-Chloro-4,6-diMethoxyaniline Hydrochloride;6-chloro-2,4-dimethoxyaniline
• CAS NO: 82485-84-5
• Molecular Formula: C₈H₁₀ClNO₂
• Molecular Weight: 187.62
• Product Categories: Amines;Aromatics
• Mol File: 82485-84-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 285.6 °C at 760 mmHg
• Flash Point: 126.6 °C
• Appearance: /
• Density: 1.237 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• Solubility: DMSO, Methanol
• CAS DataBase Reference: (2-Chloro-4,6-dimethoxyphenyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Chloro-4,6-dimethoxyphenyl)amine(82485-84-5)
• EPA Substance Registry System: (2-Chloro-4,6-dimethoxyphenyl)amine(82485-84-5)

Safety Data

• Hazardous Substances Data: 82485-84-5(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 104-91-6 p-nitrosophenol 
• 637-62-7 p-benzoquinone oxime 
• 108-95-2 phenol 

Downstream Products

• 138849-50-0 N-pivaloyl-6-chloro-2,4-dimethoxyaniline 
• 138849-61-3 N,N-dimethyl-N'-(6-chloro-2,4-dimethoxyphenyl)formamidine 
• 1026753-49-0 6-chloro-N⁴-(2-chloro-4,6-dimethoxy-phenyl)-2-methyl-pyrimidine-4,5-diamine 
• 220953-26-4 6-(2-chloro-4,6-dimethoxy-phenylamino)-2-methyl-5-nitro-3H-pyrimidin-4-one 
• 138849-51-1 6-chloro-5-acetylamino-2,4-dimethoxybenzaldehyde 
• 138849-54-4 4-chloro-3-pivaloylamino-2,6-dimethoxybenzaldehyde 
• 138849-52-2 6-chloro-5-pivaloylamino-2,4-dimethoxybenzaldehyde 
• 138849-53-3 4-chloro-3-pivaloylamino-2,6-dimethoxybenzoic acid 
• 99848-45-0 1-chloro-2-iodo-3,5-dimethoxybenzene 
• 138849-49-7 N-acetyl-6-chloro-2,4-dimethoxyaniline 
• 7051-16-3 1-chloro-3,5-dimethoxybenzene 
• 197799-16-9 N-(2-chloro-4,6-dimethoxyphenyl)-1-(1-ethylpropyl)-6-methyl-1H-1,2,3-triazolo[4,5-c] pyridin-4-amine 
• 82477-60-9 2-chloro-4,6-dimethoxybenzoic acid 
• 82477-61-0 2-chloro-4,6-dimethoxybenzaldehyde 

Relevant articles and documents

Synthesis of sterically hindered polychlorinated biphenyl derivatives

A series of sterically hindered (methoxylated) polychlorinated biphenyl derivatives were synthesized using the Suzuki and the Ullmann coupling reactions. The Suzuki coupling with Pd(dba)2-dicyclohexylphosphino-2,6- dimethoxybiphenyl (DPDB) gave better yields (65-98%) compared to the classic Ullmann coupling reaction (20-38%). Despite the reactive catalyst system, no significant coupling with aromatic chlorine substituents was observed. Crystal structure analysis of four PCB derivatives revealed solid state dihedral angles ranging from 69.7 to 81.0, which indicates that these highly ortho-substituted PCB derivatives have some conformational flexibility. Georg Thieme Verlag Stuttgart.

Reaction of Some 1,4-Benzoquinone Mono-oximes with Methanolic Hydrogen Chloride

When 2-methyl-1,4-benzoquinone 4-oxime (1) reacted with methanolic hydrogen chloride at 25-30 deg C the product was 2-chloro-4,6-dimethoxy-3-methylaniline (2).Similarly 1,4-benzoquinone 4-oxime (7) gave 2-chloro-4,6-dimethoxyaniline (8), 3-methyl-1,4-benzoquinone 4-oxime (11) gave 2-chloro-4-methoxy-6-methoxymethylaniline (12) and 2-chloro-4-methoxy-6-methylaniline (13), and 2-methoxy-1,4-benzoquinone 4-oxime (19) gave 2-chloro-4,5-dimethoxyaniline (20).