82547-30-6

Basic information

• Product Name: 3-(5-BROMO-2-METHOXYPHENYL)PROPANOIC ACID
• Synonyms: 3-(5-BROMO-2-METHOXYPHENYL)PROPANOIC ACID;5-BROMO-2-METHOXYPHENYLPROPANOIC ACID;OTAVA-BB 7020683859;3-(5-BroMo-2-Methoxyphenyl)propionic acid, 96%
• CAS NO: 82547-30-6
• Molecular Formula: C₁₀H₁₁BrO₃
• Molecular Weight: 259.11
• Mol File: 82547-30-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 114-116℃
• Appearance: /
• CAS DataBase Reference: 3-(5-BROMO-2-METHOXYPHENYL)PROPANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(5-BROMO-2-METHOXYPHENYL)PROPANOIC ACID(82547-30-6)
• EPA Substance Registry System: 3-(5-BROMO-2-METHOXYPHENYL)PROPANOIC ACID(82547-30-6)

Safety Data

• Hazardous Substances Data: 82547-30-6(Hazardous Substances Data)

Upstream product

• 996-82-7 sodium diethylmalonate 
• 7017-52-9 4-bromo-2-(chloromethyl)-1-methoxybenzene 
• 6342-77-4 2-methoxy-benzenepropanoic acid 
• 7664-93-9 sulfuric acid 
• 3132-99-8 m-bromobenzoic aldehyde 
• 1528736-46-0 (E)-methyl 3-(5-bromo-2-methoxyphenyl)acrylate 
• 1261878-63-0 methyl 3-(5-bromo-2-methoxyphenyl)propionate 
• 25016-01-7 5-bromo-2-methoxybenzaldehyde 

Downstream Products

• 82547-31-7 3-(5-cyano-2-methoxyphenyl)propionic acid 
• 1616372-56-5 3-(3'-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)-4-methoxy-[1,1'-biphenyl]-3-yl)propanoic acid 
• 860254-79-1 3-(5-bromo-2-methoxy-phenyl)-propionyl chloride 
• 20921-00-0 6-bromo-3,4-dihydro-2H-1-benzopyran-2-one 
• 82547-32-8 3-(5-aminomethyl-2-methoxyphenyl)propionic acid 

Relevant articles and documents

Design and synthesis of novel meta-linked phenylglycine macrocyclic FVIIa inhibitors

Two novel series of meta-linked phenylglycine-based macrocyclic FVIIa inhibitors have been designed to improve the rodent metabolic stability and PK observed with the precursor para-linked phenylglycine macrocycles. Through iterative structure-based design and optimization, the TF/ FVIIa Ki was improved to subnanomolar levels with good clotting activity, metabolic stability, and permeability.

MACROCYCLIC FACTOR VIIA INHIBITORS

The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are Factor VIIa inhibitors which may be used as medicaments.