82702-31-6

Basic information

• Product Name: 3-BROMO-4-FLUORO-BENZOIC ACID METHYL ESTER
• Synonyms: 3-BROMO-4-FLUORO-BENZOIC ACID METHYL ESTER;METHYL 3-BROMO-4-FLUOROBENZOATE;RARECHEM AL BF 0277;Methyl 3-bromo-4-fluorobenzoate 98%;Methyl3-bromo-4-fluorobenzoate98%;Methyl 3-bromo-4-fluorobenzene
• CAS NO: 82702-31-6
• Molecular Formula: C₈H₆BrFO₂
• Molecular Weight: 233.03
• Product Categories: blocks;Bromides;Carboxes;FluoroCompounds;Aromatic Esters;Acids & Esters;Bromine Compounds;Fluorine Compounds
• Mol File: 82702-31-6.mol
• Article Data: 12

Chemical Properties

• Melting Point: 26-28
• Boiling Point: 245.3 °C at 760 mmHg
• Flash Point: 102.1 °C
• Appearance: /
• Density: 1.577 g/cm³
• Storage Temp.: Keep Cold
• CAS DataBase Reference: 3-BROMO-4-FLUORO-BENZOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-4-FLUORO-BENZOIC ACID METHYL ESTER(82702-31-6)
• EPA Substance Registry System: 3-BROMO-4-FLUORO-BENZOIC ACID METHYL ESTER(82702-31-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 82702-31-6(Hazardous Substances Data)

Usage

Chemical Properties

off-white powder

Upstream product

• 1007-16-5 3-bromo-4-fluorobenzoic acid 
• 67-56-1 methanol 
• 78239-65-3 3-bromo-4-fluoro-benzoic acid fluoride 
• 403-33-8 methyl 4-flurobenzoate 

Downstream Products

• 1026729-53-2 4-fluoro-3-isopropyl-benzaldehyde 
• 370867-69-9 3-ethyl-4-fluoro-benzaldehyde 
• 370867-75-7 trans-3-ethyl-4-fluorocinnamic acid tert-butyl ester 
• 370867-76-8 trans-4-fluoro-3-isopropylcinnamic acid tert-butyl ester 
• 887333-65-5 methyl 3-bromo-4-(5-formyl-2-methoxyphenoxy)benzoate 
• 1332637-07-6 methyl 3-bromo-4-(2-(methoxycarbonyl)phenoxy)benzoate 
• 1262328-73-3 4-(4-formyl-2-methoxyphenoxy)-3-brobromobenzoicmethyl acid methyl ester 
• 1262328-51-7 4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-bromobenzoic acid methyl ester 
• 1254043-33-8 methyl 3-bromo-4-[4-(2-hydroxyethyl)piperazin-1-yl]benzoate 
• 1197357-83-7 methyl 4-fluoro-3-(pyridin-2-ylethynyl)benzoate 
• 1001922-29-7 1-(3-bromo-4-fluorophenyl)-2-(2-methylsulfanylpyrimidin-4-yl)ethanone 
• 948018-63-1 3-bromo-4-(4-methyl-piperazin-1-yl)-benzoic acid methyl ester 

Relevant articles and documents

Bromine structural domain inhibitor compound and application thereof

The invention relates to a bromine structural domain inhibitor and provides a compound shown in a general formula I, pharmaceutical salt, an enantiomer, a diastereoisomer, an atropisomer, racemate, apolymorphic substance and solvate of the compound or an isotope labelled compound (including a deuterium substituted compound), a preparation method of the compound, pharmaceutical composition containing the compound and an application of the above components in pharmaceuticals.

Syntheses and evaluation of anti-inflammatory, analgesic and ulcerogenic activities of 1,3,4-oxadiazole and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives

Several 2,5-disubstituted-1,3,4-oxadiazoles (4af) and 3,6-disubstituted-1, 2,4-triazolo[3,4-b]-1,3,4-thiadiazoles (7af) were synthesized and characterized by elemental analyses and spectral data. These compounds were screened for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities. Compound 7c showed excellent anti-inflammatory and remarkable analgesic activity with reduced ulcerogenic and lipid peroxidation activity when compared with ibuprofen.

CARBINOL DERIVATIVES HAVING HETEROCYCLIC LINKER

[Object] It is to provide a novel LXRβ agonist useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate: (wherein, each V and W independently show N or C—R7; each X and Y independently show CH2, C═O, SO2, etc; Z shows CH or N; each R1, R2 and R7 independently show a hydrogen atom, C1-8 alkyl group, etc.; R3 shows C1-8 alkyl group; R4 shows an optionally substituted C6-10 aryl group or an optionally substituted 5- to 11-membered heterocyclic group; R5 and R6 show a hydrogen atom, etc.; L shows a C1-8 alkyl chain optionally substituted with an oxo group, etc.; and n shows any integer of 0 to 2.)