827031-83-4

Basic information

• Product Name: Verubulin
• Synonyms: Verubulin;MPC-6827;(4-Methoxyphenyl)(methyl)(2-methylquinazolin-4-yl)amine;MX 128495;N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine;N-(4-Methoxyphenyl)-N,2-diMethylquinazolin-4-aMine;4-QuinazolinaMine,N-(4-Methoxyphenyl)-N,2-diMethyl-
• CAS NO: 827031-83-4
• Molecular Formula: C17H17N3O
• Molecular Weight: 279.33638
• Mol File: 827031-83-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 86-90℃
• Appearance: /
• Density: 1.189
• CAS DataBase Reference: Verubulin(CAS DataBase Reference)
• NIST Chemistry Reference: Verubulin(827031-83-4)
• EPA Substance Registry System: Verubulin(827031-83-4)

Safety Data

• Hazardous Substances Data: 827031-83-4(Hazardous Substances Data)

Usage

General Description

Verubulin, also known as ASLAN003, is a small molecule chemical compound that is being investigated as a potential anticancer agent. It is a selective inhibitor of the pan-RAF kinase family, which plays a crucial role in cell signaling pathways that regulate cell growth and survival. Verubulin has shown promising preclinical and early clinical trial data in various cancer types, including colorectal, lung, and liver cancers. It has demonstrated the ability to inhibit tumor growth and induce tumor cell death in preclinical studies, and it is currently being evaluated in phase II clinical trials for its safety and efficacy in cancer patients. If successful, verubulin could offer a new targeted treatment option for cancer patients with RAF kinase-driven tumors.

Upstream product

• 6484-24-8 2-methyl-4-chloroquinazoline 
• 5961-59-1 N-methyl-N-(4-methoxyphenyl)amine 
• 1363721-18-9 (2-methylquinazolin-4-yl)-4-methylbenzenesulfonate 
• 1769-24-0 2-methyl-4-quinazolone 
• 102669-53-4 N'-(2-cyanophenyl)-N,N-dimethylacetamidine 
• 677748-57-1 N-(4-methoxyphenyl)-2-methylquinazolin-4-amine 
• 74-88-4 methyl iodide 

Relevant articles and documents

Efficient N-arylation of 4-chloroquinazolines en route to novel 4-anilinoquinazolines as potential anticancer agents

Microwave-mediated N-arylation of 4-chloroquinazolines in THF/H2O rapidly and efficiently afforded a library of novel 6-halo-2- phenyl-substituted 4-anilinoquinazolines. The methodology was compatible with numerous ortho-, meta-, and para-substituted N-methylanilines as well as substituted anilines and furnished the corresponding 4-anilinoquinazolines in good yields. Preliminary screening of the synthesized compounds against tumor cells (HCT-116 and T98G) showed promising antiproliferative properties.

Radiosynthesis and in Vivo Evaluation of [11C]MPC-6827, the First Brain Penetrant Microtubule PET Ligand

Abnormalities of microtubules (MTs) are implicated in the pathogenesis of many CNS diseases. Despite the potential of an MT imaging agents, no PET ligand is currently available for in vivo imaging of MTs in the brain. We radiolabeled [11C]MPC-6

Microwave-accelerated Dimroth rearrangement for the synthesis of 4-anilino-6-nitroquinazolines. Application to an efficient synthesis of a microtubule destabilizing agent

A useful and rapid access to 4-anilino-6-nitroquinazolines was investigated in a multi-gram scale via microwave-accelerated condensation and Dimroth rearrangement of the starting anilines with imines obtained by reaction of anthranilonitriles with formamide dimethylacetal. A novel short and efficient route to Azixa (EPi28495, MPC-6827), a microtubule destabilizing agent and apoptosis inducer, was performed with success demonstrating that well controlled parameters offer comfortable using of microwave technology with safe and environmental benefits.