827582-70-7

Basic information

• Product Name: N-(4-nitrophenyl)-4-oxo-4-(pyrrolidin-1-yl)butanamide
• Synonyms: N-(4-nitrophenyl)-4-oxo-4-(pyrrolidin-1-yl)butanamide
• CAS NO: 827582-70-7
• Molecular Weight: 291.307
• Mol File: 827582-70-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-nitrophenyl)-4-oxo-4-(pyrrolidin-1-yl)butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-nitrophenyl)-4-oxo-4-(pyrrolidin-1-yl)butanamide(827582-70-7)
• EPA Substance Registry System: N-(4-nitrophenyl)-4-oxo-4-(pyrrolidin-1-yl)butanamide(827582-70-7)

Safety Data

• Hazardous Substances Data: 827582-70-7(Hazardous Substances Data)

Upstream product

• 123-75-1 pyrrolidine 
• 5502-63-6 p-nitrosuccinanilic acid 

Downstream Products

• 1191091-09-4 N-(4-aminophenyl)-4-oxo-4-(pyrrolidin-1-yl)butanamide 

Relevant articles and documents

Design, synthesis and evaluation of 4,5-di-substituted acridone ligands with high G-quadruplex affinity and selectivity, together with low toxicity to normal cells

A series of 4,5-di-substituted acridones have been designed and synthesized. Several compounds show high affinity for telomeric G-quadruplex DNA in classical and competition FRET assays, together with low duplex DNA affinity, although they do not show activity in a telomerase assay or evidence of telomere shortening. They have low toxicity against a panel of cancer cell lines and a normal human fibroblast line, and produce potent senescence-based long-term growth arrest in the MCF7 and A549 cancer cell lines.