827603-88-3Relevant articles and documents
Synthesis and determination of the absolute stereochemistry of the enantiomers of adrafinil and modafinil
Osorio-Lozada, Antonio,Prisinzano, Thomas,Olivo, Horacio F.
, p. 3811 - 3815 (2007/10/03)
Both enantiomers of modafinil, adrafinil, modafinic acid and ethyl modafinate were prepared from the diastereomers formed by reacting racemic β-sulfinyl carboxylic acid with (4R)-phenyl-thiazolidinethione. The absolute stereochemistry of the sulfoxide group was confirmed via X-ray analysis of one of the thiazolidinethione diastereomers.