828254-18-8

Basic information

• Product Name: Boc-(S)-2-(aMinoMethyl)-4-Methylpentanoic acid
• Synonyms: Boc-(S)-2-(aMinoMethyl)-4-Methylpentanoic acid;(Tert-Butoxy)Carbonyl (S)-2-(Aminomethyl)-4-methylpentanoic acid
• CAS NO: 828254-18-8
• Molecular Formula: C12H23NO4
• Molecular Weight: 245.31532
• Mol File: 828254-18-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 56-57 °C
• Boiling Point: 374.3±25.0 °C(Predicted)
• Appearance: /
• Density: 1.046±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.49±0.21(Predicted)
• CAS DataBase Reference: Boc-(S)-2-(aMinoMethyl)-4-Methylpentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-(S)-2-(aMinoMethyl)-4-Methylpentanoic acid(828254-18-8)
• EPA Substance Registry System: Boc-(S)-2-(aMinoMethyl)-4-Methylpentanoic acid(828254-18-8)

Safety Data

• Hazardous Substances Data: 828254-18-8(Hazardous Substances Data)

Usage

General Description

Boc-(S)-2-(aminomethyl)-4-methylpentanoic acid, also known as Boc-S-AMP, is a chemical compound commonly used in the synthesis of peptides. It is a derivative of the amino acid leucine and is often employed as a chiral auxiliary in the production of peptide-based drugs. Boc-(S)-2-(aMinoMethyl)-4-Methylpentanoic acid is a protected form of the amino acid, with the Boc (tert-butyloxycarbonyl) group serving to protect the amine group from unwanted reactions. Boc-S-AMP is utilized in organic and medicinal chemistry for the creation of complex peptide structures with specific biological properties. Its modular and versatile nature makes it a valuable tool in the development of new pharmaceuticals and biologically active molecules.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
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• 132605-95-9 2-(aminomethyl)-4-methylpentanoic acid hydrochloride 
• 114438-66-3 (-)-methyl-(S)-2-bromo-4-methylpentanoate 
• 28659-87-2 (S)-2-bromo-4-methylpentanoic acid 
• 61-90-5 L-leucine 
• 887143-09-1 methyl 2-[(dibenzylamino)methyl]-4-methylpentanoate 
• 776327-14-1 2-aminomethyl-4-methyl-pentanoic acid methyl ester 
• 100869-07-6 2-(aminomethyl)-4-methylpentanoic acid 
• 262301-37-1 N-[3-(N'-diphenylmethylene)-2-isobutylaminopropionyl] sultam 
• 887143-14-8 (2S)-N-{(2R)-2-[(dibenzylamino)methyl]-4-methylpentanoyl}camphorsultam 
• 927830-83-9 (R)-2-Aminomethyl-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-4-methyl-pentan-1-one 
• 887143-13-7 (S)-N-(2-bromo-4-methyl-pentanoyl) camphorsultam 

Relevant articles and documents

Beta amino acid-modified and fluorescently labelled kisspeptin analogues with potent KISS1R activity

Kisspeptin analogues with improved metabolic stability may represent important ligands in the study of the kisspeptin/KISS1R system and have therapeutic potential. In this paper we assess the activity of known and novel kisspeptin analogues utilising a du

Practical synthesis of enantiomerically pure β2-amino acids via proline-catalyzed diastereoselective aminomethylation of aldehydes

Proline-catalyzed diastereoselective aminomethylation of aldehydes using a chiral iminium ion, generated from a readily prepared precursor, provides α-substituted-β-amino aldehydes with 85:15 to 90: 10 dr. The α-substituted-β-amino aldehydes can be reduce

New scalable asymmetric aminomethylation reaction for the synthesis of β2-amino acids

β-Amino acids are useful tools in the design of peptidomimetics, and the development of new methods for their syntheses, particularly the synthesis of β2-amino acids, remains an important challenge. Here we report a new scalable route based on the aminomethylation of silyl ketene N,O-acetals by Mannich-type iminium electrophiles. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.