828272-16-8Relevant articles and documents
Novel examples of the N-methyl effect on cyclisations of N-Boc derivatives of amino alcohols. A theoretical study
Hamdach,El Hadrami,Testa,Gil,Zaballos-García,Sepúlveda-Arques,Arroyo,Domingo
, p. 12067 - 12073 (2004)
New examples of the N-methyl effect on the cyclisation of N-tert-butoxycarbonyl derivatives of amino alcohols are reported. Ab initio studies for the displacement step with formation of the five-membered heterocycle indicate that the increase of the nucleophile character of the carbonyl oxygen of the carbamate group with the N-methyl substitution is responsible for the acceleration of the cyclisation step. Graphical Abstract