828934-40-3

Basic information

• Product Name: S-(+)-Etomoxir
• Synonyms: DZLOHEOHWICNIL-KRWDZBQOSA-N
• CAS NO: 828934-40-3
• Molecular Formula: C17H23ClO4
• Molecular Weight: 326.81512
• Product Categories: Chiral Reagents;Inhibitors
• Mol File: 828934-40-3.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: S-(+)-Etomoxir(CAS DataBase Reference)
• NIST Chemistry Reference: S-(+)-Etomoxir(828934-40-3)
• EPA Substance Registry System: S-(+)-Etomoxir(828934-40-3)

Safety Data

• Hazardous Substances Data: 828934-40-3(Hazardous Substances Data)

Upstream product

• 64-67-5 diethyl sulfate 
• 124083-18-7 {(S)-2-[6-(4-Chloro-phenoxy)-hexyl]-oxiranyl}-methanol 
• 106-48-9 4-chloro-phenol 
• 191412-56-3 (R)-2-(6-Hydroxy-hexyl)-oxirane-2-carboxylic acid ethyl ester 
• 314263-47-3 (R)-8-(4-Chloro-phenoxy)-2-hydroxy-2-methanesulfonyloxymethyl-octanoic acid ethyl ester 
• 37136-99-5 1-((6-bromohexyl)oxy)-4-chlorobenzene 
• 82258-37-5 ethyl 2-[6-(p-chlorophenoxy)hexyl]acrylate 
• 82258-39-7 6-(4-chlorophenoxy)hexylmalonic acid diethyl ester 
• 191412-50-7 (S)-1-(8-Benzyloxy-2-methylene-octanoyl)-pyrrolidine-2-carboxylic acid ethyl ester 
• 191412-52-9 (3S,8aS)-3-(6-Benzyloxy-hexyl)-3-bromomethyl-tetrahydro-pyrrolo[2,1-c][1,4]oxazine-1,4-dione 
• 191412-51-8 (S)-1-(8-Benzyloxy-2-methylene-octanoyl)-pyrrolidine-2-carboxylic acid 
• 191412-48-3 8-Benzyloxy-2-methylene-octanoic acid ethyl ester 
• 191412-55-2 (S)-2-Bromomethyl-2,8-dihydroxy-octanoic acid methyl ester 
• 191412-53-0 (S)-2-Bromomethyl-2,8-dihydroxy-octanoic acid 

Relevant articles and documents

A Unified and Desymmetric Approach to Chiral Tertiary Alkyl Halides

Enantioenriched tertiary alkyl halides are prevalent in bioactive molecules and can serve as versatile synthetic intermediates to construct complex structures. While conventional access to these motifs often hinges on stereoselective carbon-halogen or carbon-carbon bond formation reactions, desymmetric approaches using halogenated and prochiral tetrasubstituted carbons are largely elusive in comparison. Here, we report that a suite of dinuclear zinc catalysts with a prolinol- or pipecolinol-derived tetradentate ligand can reductively desymmetrize a large collection of easily available halomalonic esters to α-halo-β-hydroxyesters. These polyfunctionalized tertiary alkyl fluorides, chlorides, and bromides proved to be useful intermediates toward fluorinated drug analogs and polyhalogenated monoterpenes. The facile intramolecular epoxidation of the chiral chloride and bromide products has also enabled expeditious access to natural products containing tertiary alcohol motifs.

Asymmetric synthesis of (R)-(+)-etomoxir via enzymatic resolution

An asymmetric synthesis of (R)-(+)-etomoxir 3, employing enzymatic resolution of ethyl 2-alkyl-2,3-dihydroxypropionate using Amano AK via transacylation is reported. Copyright (C) 2000 Elsevier Science Ltd.

Medicaments for the treatment of cardiac insufficiency

The use of oxirane carboxylic acids having the formula I: STR1 in which R1 and R2 are independently selected from hydrogen, halogen, straight-chain or branched 1-4C alkyl groups, straight-chain or branched 1-4C alkoxy groups, nitro or trifluoromethyl; R3 is hydrogen or straight-chain or branched 1-4C alkyl; Y is --O--(CH2)m --, where m is zero or a whole number from 1 to 4, and n is a whole number from 2 to 8, or a pharmaceutically acceptable salt thereof, is disclosed for treating heart insufficiency.