82941-32-0Relevant articles and documents
Compartmentalization of Incompatible Polymers within Metal–Organic Frameworks towards Homogenization of Heterogeneous Hybrid Catalysts for Tandem Reactions
Zhao, Jin-Hao,Yang, Yong,Che, Jin-Xin,Zuo, Jun,Li, Xiao-Hua,Hu, Yong-Zhou,Dong, Xiao-Wu,Gao, Liang,Liu, Xin-Yuan
, p. 9903 - 9909 (2018)
New catalytic systems that contain incompatible catalytic sites were constructed by the in situ polymerization of acidic and basic polymers into metal–organic frameworks, which resulted in highly porous, recyclable, and durable catalytic composites with excellent compartmentalization, so that opposing agents were spatially isolated. These synthesized hybrid catalysts exhibited excellent catalytic activity for one-pot “wolf and lamb” reactions (deacetalization/Knoevenagel or Henry), which was attributed to their unique characteristic of having a locally homogeneous, but globally heterogeneous, structure.
A Machine-assisted flow synthesis of SR48692: A probe for the investigation of neurotensin receptor-1
Battilocchio, Claudio,Deadman, Benjamin J.,Nikbin, Nikzad,Kitching, Matthew O.,Baxendale, Ian R.,Ley, Steven V.
supporting information, p. 7917 - 7930 (2013/07/19)
Here we report the direct comparison of a conventional batch mode synthesis of Meclinertant (SR48692, 1), a neurotensin receptor-1 antagonist, with its machine-assisted flow chemistry alternative. By using these enabling tools, combined with solid-supported reagents and scavengers, many process advantages were observed. Care, however, must be taken not to convert these techniques into expensive solutions to problems that do not exist. Copyright
Polymer-bound aluminium salen complex as reusable catalysts for CO 2 insertion into epoxides
Alvaro, Mercedes,Baleizao, Carlos,Carbonell, Esther,El Ghoul, Mostafa,García, Hermenegildo,Gigante, Barbara
, p. 12131 - 12139 (2007/10/03)
Two polymeric aluminium salen complexes in where the backbones are either a partially crosslinked polystyrene [(Al(salen)/PS)] or poly(ethylene glycol bismethacrylate) [(Al(salen)/PEA)] have been synthesised and used for the carbon dioxide insertion into epoxides to form cyclic carbonates. The catalytic activity of these polymers is similar to that of the unsupported aluminium salen complexes, and the polymeric catalysts can be easily separated from the reaction mixture and reusable in consecutives runs. The activity and reusability of the polymeric salen complex depends on the nature of the polymer: PEA being a polymer with a high oxygen content in the backbone enhances the initial activity as compared to PS, but Al(salen)/PEA exhibits lower stability as compared to Al(salen)/PS and a Al depletion occurs upon use. The presence of nucleophiles such as N-methylimidazole or N,N-dimethylaminopyridine in excess increases the catalytic activity of the polymeric Al(salen) catalyst. Also polymeric nucleophiles have been found to be suitable reusable co-catalysts for this reaction.
