82961-77-1

Basic information

• Product Name: 3-OXO-4-(CBZ-AMINO)-BUTANOIC ACID METHYL ESTER
• Synonyms: 3-OXO-4-(CBZ-AMINO)-BUTANOIC ACID METHYL ESTER;Methyl 4-(((benzyloxy)carbonyl)aMino)-3-oxobutanoate;Methyl 4-(Cbz-AMino)-3-oxobutanoate;3-oxo-4-[[(phenylMethoxy)carboynyl]aMino-butanoicacidMethylester;4-Benzyloxycarbonylamino-3-oxo-butyric acid methyl ester
• CAS NO: 82961-77-1
• Molecular Formula: C₁₃H₁₅NO₅
• Molecular Weight: 265.263
• Mol File: 82961-77-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 49-51 °C
• Boiling Point: 414.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.218±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.10±0.46(Predicted)
• CAS DataBase Reference: 3-OXO-4-(CBZ-AMINO)-BUTANOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-OXO-4-(CBZ-AMINO)-BUTANOIC ACID METHYL ESTER(82961-77-1)
• EPA Substance Registry System: 3-OXO-4-(CBZ-AMINO)-BUTANOIC ACID METHYL ESTER(82961-77-1)

Safety Data

• Hazardous Substances Data: 82961-77-1(Hazardous Substances Data)

Usage

General Description

3-OXO-4-(CBZ-AMINO)-BUTANOIC ACID METHYL ESTER is a chemical compound with the molecular formula C11H15NO5. It is a methyl ester derivative of 3-oxo-4-(CBZ-amino)-butanoic acid and is often used in chemical and pharmaceutical research. 3-OXO-4-(CBZ-AMINO)-BUTANOIC ACID METHYL ESTER is a derivative of the amino acid gamma-aminobutyric acid (GABA) and is known to possess a variety of pharmacological activities. It is commonly used as a building block in the synthesis of pharmaceuticals and other biologically active compounds. Additionally, it has been studied for its potential use in the treatment of neurological disorders and as a precursor for the synthesis of GABA analogs. Overall, 3-OXO-4-(CBZ-AMINO)-BUTANOIC ACID METHYL ESTER is a versatile chemical compound with a wide range of potential applications in the fields of chemistry and pharmacology.

Upstream product

• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 38330-80-2 monomethyl monopotassium malonate 
• 22586-32-9 N-Benzyloxycarbonylglycine imidazolide 
• 57907-72-9 Methyl hydrogen malonate dianion magnesium chelate 
• 67-56-1 methanol 
• 82961-72-6 5-(N-Z-glycyl)-2,2-dimethyl-1,3-dioxane-4,6-dione 

Downstream Products

• 1361254-00-3 (10-oxo-2,3,5,6-tetrahydro-1H,4H,10H-11-oxa-3a-aza-benzo[de]anthracen-8-ylmethyl)carbamic acid benzyl ester 
• 161971-54-6 methyl (RS)-<4-(benzyloxycarbonyl)amino>-3-hydroxybutyrate 
• 141734-41-0 (R)-4-Benzyloxycarbonylamino-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-butyric acid methyl ester 
• 80503-94-2 (R)-4-<(Benzyloxycarbonyl)amino>-3-hydroxybutanoic acid 
• 119960-08-6 N-Cbz-GABOB methyl ester 

Relevant articles and documents

Synthesis of novel 3D-rich α-amino acid-derived 3-pyrazolidinones

Synthetic approaches towards novel 3-pyrazolidinone derivatives functionalized at positions N(1) and/or C(5) were studied. 5-Aminoalkyl-3-pyrazolidinones were prepared in four steps from N-protected glycines via Masamune-Claisen homologation, reduction, O

Chain extension of amino acid skeletons: Preparation of ketomethylene isosteres

Ketomethylene isosteric replacements for peptide bonds were generated through a zinc carbenoid-mediated chain extension reaction in which a variety of amino acid-derived β-keto esters are converted to γ-keto esters in a single step. The reaction tolerates a variety of protecting groups and amino acid side chains with no epimerization of the amino acid stereocenter.

Baker's yeast reduction of N-protected methyl 4-amino-3-oxobutanoates and 3-oxopentanoates

Baker's yeast reduction of N-tert-butoxycarbonyl (Boc) or N-benzyloxycarbonyl (Cbz) protected methyl 4-amino-3-oxopentanoates 4b-e and 4-amino-3-oxobutanoates 7a,b stereoselectively afforded the erythro-hydroxy esters 5b-e and (R)-hydroxy esters 8a,b, res