83124-74-7

Basic information

• Product Name: 4-ethoxy-1,1,1-trichloro-3-buten-2-one
• Synonyms: 4-ethoxy-1,1,1-trichloro-3-buten-2-one;1-Ethoxy-4,4,4-trichloro-3-oxo-1-butene;1,1,1-Trichloro-4-ethoxy-...
• CAS NO: 83124-74-7
• Molecular Formula: C₆H₇Cl₃O₂
• Molecular Weight: 217.48
• Mol File: 83124-74-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 200℃
• Flash Point: 72℃
• Appearance: /
• Density: 1.368
• CAS DataBase Reference: 4-ethoxy-1,1,1-trichloro-3-buten-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethoxy-1,1,1-trichloro-3-buten-2-one(83124-74-7)
• EPA Substance Registry System: 4-ethoxy-1,1,1-trichloro-3-buten-2-one(83124-74-7)

Safety Data

• Hazardous Substances Data: 83124-74-7(Hazardous Substances Data)

Usage

General Description

4-ethoxy-1,1,1-trichloro-3-buten-2-one, also known as ethyl 2,2,2-trichloro-4-ethoxy-3-butenate, is a chemical compound with the molecular formula C6H9Cl3O2. It is a colorless liquid that is commonly used as a pesticide and herbicide. It is also used as an intermediate in the synthesis of other organic compounds. 4-ethoxy-1,1,1-trichloro-3-buten-2-one is an irritant to the skin, eyes, and respiratory system, and can cause headaches, dizziness, and nausea if inhaled or ingested in large amounts. It is important to handle this chemical with care and follow proper safety protocols when using it.

Upstream product

• 64-17-5 ethanol 
• 109-92-2 ethyl vinyl ether 
• 76-02-8 trifluoroacetyl chloride 
• 83124-64-5 1,1,1,4-tetrachloro-4-ethoxy-butan-2-one 

Downstream Products

• 51-17-2 benzoimidazole 
• 24811-78-7 Pyrimido<1,2-a>benzimidazol-2(1H)-on 
• 1069130-63-7 C₁₀H₉Cl₃O₃ 
• 1444031-07-5 1-(pentafluorophenyl)-5-(trichloromethyl)-4,5-dihydro-5-hydroxy-1H-pyrazole 
• 6191-97-5 3,3-diethoxypropanoic acid 
• 1403656-82-5 3-ethoxy-1-(phenylmethyl)pyrrolidine-2,5-dione 
• 1403656-83-6 C₁₄H₁₇NO₃ 
• 14384-66-8 4,5-dihydro-5-oxo-[1,2,4]triazolo[1,5-a]pyrimidine 

Relevant articles and documents

C-Bridged Bispyrrolidines and Bispiperidines as New Ligands

The preparation of methylene-bridged C2-symmetric nitrogen-heterocycles as a new class of ligands is described, including methylene-bridged pyridines, quinolones, piperidines and pyrrolidines. These methylene-bridged aromatic systems are obtained via a microwave assisted Ziegler-type reaction. The separation of diastereomers and the application of the copper complexes of these ligands for cyclopropanation reactions proves the applicability of these new types of ligands.

Superacidic Cyclization of Activated Anthranilonitriles into 2-Unsubstituted-4-aminoquinolines

4-Aminoquinolines were prepared in a three-step synthesis starting from substituted anthranilonitriles. The condensation on 1,1,1-trichloro-4-ethoxybut-3-enone proceeded efficiently either neat or in refluxing EtOH. Cyclization in superacidic trifluoromethanesulfonic acid provided unstable intermediate, which upon treatment with NaOEt in ethanol, afforded the expected esters. Theoretical investigations pointed out a monoprotonated nitrilium as the reactive species during the cyclization process.

A method for synthesizing allah Geleg sandbank (by machine translation)

The invention relates to a method for preparing anti-II type diabetes drug allah Geleg sandbank method for the synthesis of bulk drug (Anagliptin). The lack of commercial synthetic allah Geleg sandbank solve the technical problems of the method. Synthetic method comprises the following steps : (1) with vinyl ether and trichloro acetyl chloride as the raw material, passes through the three-step reaction to obtain the aldehyde protected intermediates 4 ; The 3-amino-5-methyl pyrazole condensation for dehydrating and gets pyrazolo pyrimidine mother nucleus; Carboxy b ester hydrolysis to obtain 2-methyl-pyrazolo [1,5-a] pyrimidin 6-carboxylic acid 6 ; (2) to L-proline as a raw material, passes through the methyl esterification, ammoniation, acetylation, Carbonitride reaction to obtain the chiral cyano pyrrolizinone intermediate 11 ; Chiral cyano pyrrolizinone intermediate 11 And diamine fragment 12 In alkaline conditions to obtain intermediate affinity substituted 13 ; Finally, intermediate 13 Under the conditions of the hydrochloric acid removal protection Boc base namely obtain cyanopentanoyl Azolylamine intermediate 14 ; (3) 2-methyl-pyrazolo [1,5-a] pyrimidine-6-carboxylic acid 6 The cyano Azolylamine intermediate 14 The condensation conditions to obtain the bulk drug allah Geleg sandbank coupled. (by machine translation)