83191-67-7Relevant articles and documents
On the intractability of estrogen-related receptor α as a target for activation by small molecules
Hyatt, Stephen M.,Lockamy, Elizabeth L.,Stein, Rebecca A.,McDonnell, Donald P.,Miller, Aaron B.,Orband-Miller, Lisa A.,Willson, Timothy M.,Zuercher, William J.
, p. 6722 - 6724 (2008/09/17)
The estrogen-related receptor α (ERRα) is a potential target for activation in the treatment of metabolic disease. To date, no small-molecule agonists of ERRα have been identified despite several high-throughput screening campaigns. We describe the synthesis and profiling of a small array of compounds designed on the basis of a previously reported agonist-bound crystal structure of the closely related receptor ERRγ. The results suggest that ERRα may be intractable as a direct target for pharmacologic activation.
COMPARATIVE STUDIES ON THE PREPARATION OF ISOMERIC HYDROXYBENZAMIDES.
SCHOENENBERGER,HOLZHEU-ECKARDT,BAMANN
, p. 324 - 328 (2007/10/05)
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