83265-53-6

Basic information

• Product Name: 2-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID
• Synonyms: 2-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID;BUTTPARK 24\07-92;Benzoic acid, 2-amino-5-(trifluoromethyl)-;4-Amino-3-carboxybenzotrifluoride, 2-Carboxy-4-(trifluoromethyl)aniline;2-Amino-5-trifuloromethylbenzoic acid;4-Amino-3-carboxybenzotrifluoride
• CAS NO: 83265-53-6
• Molecular Formula: C₈H₆F₃NO₂
• Molecular Weight: 205.1339496
• Product Categories: Benzoic acid series;Fluorine series
• Mol File: 83265-53-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 141-146℃
• Boiling Point: 301.59 °C at 760 mmHg
• Flash Point: >110°(230°F)
• Appearance: /Solid
• Density: 1.489 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.51±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID(83265-53-6)
• EPA Substance Registry System: 2-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID(83265-53-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 83265-53-6(Hazardous Substances Data)

Usage

General Description

2-Amino-5-trifluoromethyl-benzoic acid is a chemical compound that consists of a benzoic acid core with an amino group and a trifluoromethyl group attached to it. It is often used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID has the potential for several biological activities and is being studied for its potential use in drug development. It is also used as a building block in organic synthesis and has applications in the production of dyes, pigments, and other organic compounds. Additionally, 2-Amino-5-trifluoromethyl-benzoic acid may have potential industrial applications in the production of polymers and materials.

Upstream product

• 141940-29-6 2-(tert-butoxycarbonylamino)-5-(trifluoromethyl)benzoic acid 
• 117324-58-0 methyl 2-Amino-5-trifluoromethylbenzoate 
• 1214373-54-2 2-nitro-5-(trifluoromethyl)benzoic acid 
• 454-92-2 3-(trifluoromethyl)benzoic acid 
• 402-59-5 N-(4-trifluoromethylphenyl)-2-oxyiminoacetamide 
• 345-32-4 5-(trifluoromethyl)isatin 

Downstream Products

• 445480-17-1 2-((2-methylpropyl)aminocarbonyl)amino-5-trifluoromethylbenzoic acid 
• 781-94-2 6-(trifluoromethyl)-2H-benzo[d][1,3]oxazine-2,4(1H)-dione 
• 117324-58-0 methyl 2-Amino-5-trifluoromethylbenzoate 
• 16499-54-0 2-amino-5-(trifluoromethyl)benzamide 
• 16544-67-5 6-(trifluoromethyl)-3Η-quinazolin-4-one 
• 51582-75-3 2-(phenylamino)-5-(trifluoromethyl)benzoic acid 

Relevant articles and documents

Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease

Based on a multitarget strategy, a series of novel tacrine-pyrimidone hybrids were identified for the potential treatment of Alzheimer's disease (AD). Biological evaluation results demonstrated that these hybrids exhibited significant inhibitory activities toward acetylcholinesterase (AChE) and glycogen synthase kinase 3 (GSK-3). The optimal compound 27g possessed excellent dual AChE/GSK-3 inhibition both in terms of potency and equilibrium (AChE: IC50 = 51.1 nM; GSK-3β: IC50 = 89.3 nM) and displayed significant amelioration on cognitive deficits in scopolamine-induced amnesia mice and efficient reduction against phosphorylation of tau protein on Ser-199 and Ser-396 sites in glyceraldehyde (GA)-stimulated differentiated SH-SY5Y cells. Furthermore, compound 27g exhibited eligible pharmacokinetic properties, good kinase selectivity, and moderate neuroprotection against GA-induced reduction in cell viability and neurite damage in SH-SY5Y-derived neurons. The multifunctional profiles of compound 27g suggest that it deserves further investigation as a promising lead for the prospective treatment of AD.

Novel Heterocyclidene Acetamide Derivative

A compound represented by formula (I′): (wherein m, n, and p each represent 0 to 2; q represents 0 or 1; R1 represents halogen, a hydrocarbon group, a heterocyclic group, an alkoxy group, an alkoxycarbonyl group, a sulfamoyl group, a CN group,

NOVEL HETEROCYCLIDENE ACETAMIDE DERIVATIVE

A compound represented by formula (I'): (wherein m, n, and p each represent 0 to 2; q represents 0 or 1; R1 represents halogen, a hydrocarbon group, a heterocyclic group, an alkoxy group, an alkoxycarbonyl group, a sulfamoyl group, a CN group,