83282-91-1

Basic information

• Product Name: 4-Methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol
• Synonyms: 2,3,5,6-Tetrafluoro-4-methoxybenzyl alcohol;4-Methoxymethyl-2,3,5,6-Tetrafluorobenzyl;2,3,5,6-TETRAFLUORO-4-(METHOXYMETHYL)BENZYL ALCOHOL;4-METHOXYMETHYL-2,3,5,6-TERAFLUOROBENZENMETHANOL;4-Methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol;4-Methoxymethyl-2,3,5,6-Tetrafluorobenzene;4-Methoxy-2;6-tetrafluorobenzyl alcohol
• CAS NO: 83282-91-1
• Molecular Formula: C₉H₈F₄O₂
• Molecular Weight: 224.15
• EINECS: 1592732-453-0
• Product Categories: Benzhydrols, Benzyl & Special Alcohols
• Mol File: 83282-91-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 214 ºC
• Flash Point: 107 ºC
• Appearance: /
• Density: 1.407
• Vapor Pressure: 0.0928mmHg at 25°C
• Refractive Index: 1.464
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform, Methanol
• PKA: 12.85±0.10(Predicted)
• CAS DataBase Reference: 4-Methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol(83282-91-1)
• EPA Substance Registry System: 4-Methoxymethyl-2,3,5,6-tetrafluorobenzyl alcohol(83282-91-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 83282-91-1(Hazardous Substances Data)

Usage

Uses

4-Methoxymethyl-2,3,5,6-tetrafluorobenzyl Alcohol is used as a reagent in the synthesis of Metofluthrin; a potent new synthetic pyrethroid with high vapor activity against mosquitos.

InChI:InChI=1/C9H8F4O2/c1-15-3-5-8(12)6(10)4(2-14)7(11)9(5)13/h14H,2-3H2,1H3

Upstream product

• 92339-07-6 2,3,5,6-tetrafluoro-1,4-benzenedimethanol 
• 77-78-1 dimethyl sulfate 
• 64-19-7 acetic acid 
• 802294-64-0 propionic acid 
• 62172-93-4 4-(Methoxymethyl)-2,3,5,6-tetrafluorobenzoic acid 
• 942435-98-5 4-methoxymethyl-2,3,5,6-tetrafluorotoluene 
• 1634-04-4 tert-butyl methyl ether 

Downstream Products

• 271241-14-6 2,3,5,6-tetrafluoro-4-(methoxymethyl)benzyl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate 
• 240494-70-6 metofluthrin 
• 1160509-06-7 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl (1R)-trans-3-difluoromethyl-2,2-dimethylcyclopropanecarboxylate 
• 915288-13-0 [2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl-(1R)-trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate 

Relevant articles and documents

Synthesis method of 2,3,5,6-tetrafluoro-4-methoxymethyl benzyl alcohol

The invention discloses a method for synthesizing 2,3,5,6-tetrafluoro-4-methoxymethyl benzyl alcohol through 1,4-di(methoxymethyl)-2,3,5,6-tetrafluorobenzene and belongs to the technical field of organic synthesis. The method comprises the following steps: taking the 1,4-di(methoxymethyl)-2,3,5,6-tetrafluorobenzene to react in a mixed solution composed of a sulfuric acid water solution and organiccarboxylic acid; carrying out ester group hydrolysis reaction on an obtained mixture under the action of inorganic alkali; carrying out methylation reaction of hydroxyl under the action of the inorganic alkali; finally, separating and purifying to obtain the 2,3,5,6-tetrafluoro-4-methoxymethyl benzyl alcohol and recycling the 1,4-di(methoxymethyl)-2,3,5,6-tetrafluorobenzene. According to the method provided by the invention, resource utilization of the low-value 1,4-di(methoxymethyl)-2,3,5,6-tetrafluorobenzene is realized; meanwhile, the method has the advantages of cheap and easy-to-obtain reaction reagents, moderate reaction conditions, simplicity in operation, high synthesis yield, good product quality and the like, and has very high social and economic value.

TETRAFLUOROTOLUENE COMPOUND, METHOD FOR PRODUCING SAME AND USE THEREOF

A tetrafluorotoluene compound represented by the formula (1): wherein R represents a C1-C6 alkyl group, and a method for producing a tetrafluorotoluene compound represented by the formula (1) which comprises hydrogenating a tetrafluorobenzyl alcohol compound represented by the formula (2): Wherein R represents a C1-C6 alkyl group.

Method for producing 4-methoxymethy1-2,3,5,6-tetrafluorobenzenemethanol

It provides a production method of 4-methoxymethyl-2,3,5,6-tetrafluorobenzenemethanol to allow 2,3,5,6-tetrafluoro-1,4-benzenedimethanol to react with an inorganic base in water, and then add dimethyl sulfate and a water-immiscible organic solvent selected from the group consisting of hydrocarbons and ethers to the reaction mixture, or to allow 2,3,5,6-tetrafluoro-1,4-benzenedimethanol to react with an inorganic base in water and said water-immiscible organic solvent, and then to add dimethyl sulfate to the reaction mixture.