83322-23-0Relevant articles and documents
On the origins of stereoselectivity in the aminocatalytic remote alkylation of 5-alkylfurfurals
Dyguda, Mateusz,Przydacz, Artur,Krzemińska, Agnieszka,Albrecht, ?ukasz
, p. 6025 - 6031 (2019/06/24)
In the manuscript, computational studies on the remote alkylation of 5-alkylfurfurals proceeding via formation of the corresponding trienamine intermediate are presented. By the means of density functional theory (DFT) calculations and the symmetry-adapte
Single-electron transmetalation in organoboron cross-coupling by photoredox/nickel dual catalysis
Tellis, John C.,Primer, David N.,Molander, Gary A.
, p. 433 - 436 (2014/08/05)
The routine application of Csp3-hybridized nucleophiles in cross-coupling reactions remains an unsolved challenge in organic chemistry. The sluggish transmetalation rates observed for the preferred organoboron reagents in such transformations are a consequence of the two-electron mechanism underlying the standard catalytic approach. We describe a mechanistically distinct single-electron transfer-based strategy for the activation of organoboron reagents toward transmetalation that exhibits complementary reactivity patterns. Application of an iridium photoredox catalyst in tandem with a nickel catalyst effects the cross-coupling of potassium alkoxyalkyl- and benzyltrifluoroborates with an array of aryl bromides under exceptionally mild conditions (visible light, ambient temperature, no strong base). The transformation has been extended to the asymmetric and stereoconvergent cross-coupling of a secondary benzyltrifluoroborate.
Synthesis and evaluation of novel antifungal agents-quinoline and pyridine amide derivatives
Nakamoto, Kazutaka,Tsukada, Itaru,Tanaka, Keigo,Matsukura, Masayuki,Haneda, Toru,Inoue, Satoshi,Murai, Norio,Abe, Shinya,Ueda, Norihiro,Miyazaki, Mamiko,Watanabe, Naoaki,Asada, Makoto,Yoshimatsu, Kentaro,Hata, Katsura
scheme or table, p. 4624 - 4626 (2010/10/02)
Quinoline amide, azaindole amide and pyridine amides were synthesized and tested for in vitro antifungal activity against fungi. These synthesized amides have potent antifungal activity against Candida albicans and Aspergillus fumigatus. Our results sugge
