83493-63-4

Basic information

• Product Name: 2-(4-Ethoxyphenyl)-2-methylpropanol
• Synonyms: 2-(4-ETHOXY-PHENYL)-2-METHYL-PROPAN-1-OL;2-(4-ETHOXYPHENYL)-2-METHYLPROPANOL;2-(4-Ethoxyphenyl)-2-methyl-1-propanol
• CAS NO: 83493-63-4
• Molecular Formula: C₁₂H₁₈O₂
• Molecular Weight: 194.27
• Mol File: 83493-63-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 48 °C
• Boiling Point: 294.6 °C at 760 mmHg
• Flash Point: 117.9 °C
• Appearance: /
• Density: 1 g/cm³
• Vapor Pressure: 0.000729mmHg at 25°C
• Refractive Index: 1.504
• PKA: 15.01±0.10(Predicted)
• CAS DataBase Reference: 2-(4-Ethoxyphenyl)-2-methylpropanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Ethoxyphenyl)-2-methylpropanol(83493-63-4)
• EPA Substance Registry System: 2-(4-Ethoxyphenyl)-2-methylpropanol(83493-63-4)

Safety Data

• Hazardous Substances Data: 83493-63-4(Hazardous Substances Data)

Usage

General Description

2-(4-Ethoxyphenyl)-2-methylpropanol, also known as ethylhexanol, is a clear, colorless liquid with a pleasant odor. It is a commonly used chemical in various industries, including as a solvent in the production of coatings, inks, adhesives, and synthetic flavors. It is also used as a fragrance ingredient in personal care products and perfumes. Ethylhexanol is considered to have low acute toxicity and is not classified as a carcinogen, mutagen, or reproductive toxin. However, it can be a mild irritant to the skin, eyes, and respiratory tract, and precautions should be taken when handling this chemical to avoid potential health risks.

InChI:InChI=1/C12H18O2/c1-4-14-11-7-5-10(6-8-11)12(2,3)9-13/h5-8,13H,4,9H2,1-3H3

Upstream product

• 86521-64-4 2-(4-ethoxyphenyl)-2-methylpropionic acid 
• 614-72-2 1-chloro-2-ethoxybenzene 

Downstream Products

• 85002-55-7 C₁₈H₂₁NO₄ 
• 86521-64-4 2-(4-ethoxyphenyl)-2-methylpropionic acid 
• 74773-11-8 5-{4-[2-(4-Ethoxy-phenyl)-2-methyl-propoxy]-benzyl}-thiazolidine-2,4-dione 
• 85003-11-8 2-Chloro-3-{4-[2-(4-ethoxy-phenyl)-2-methyl-propoxy]-phenyl}-propionic acid methyl ester 
• 80844-07-1 etofenprox 

Relevant articles and documents

Synthesis method of 2-(4-ethoxyphenyl)-2-methyl propanol

The invention discloses a synthetic method of 2-(4-ethoxyphenyl)-2-methyl propanol, and belongs to the technical field of organic synthesis. The method comprises the following steps: performing isobutyryl chloride Friedel-Crafts acylation by taking cheap phenethyl ether as a raw material and ionic liquid as a reaction solvent, extracting and separating methyl tert-butyl ether after reaction, washing and drying an ether phase, recovering the ether phase, distilling and purifying to obtain a product, adding tert-butyl ether, adding metered liquid bromine for bromination, washing after bromination, treating and crystallizing, adding petroleum ether, refluxing, dehydrating and condensing with neopentyl glycol under the catalytic action of p-toluenesulfonic acid to obtain a condensation compound; and carrying out high-temperature transposition on the condensation compound and a catalyst zinc salt in a solvent, directly hydrolyzing with an alkaline solution, and finally reducing under the action of sodium borohydride and aluminum trichloride to obtain the 2-(4-ethoxyphenyl)-2-methyl propanol. The method is high in yield, safe, environmentally friendly and easy to operate, a small amount of aluminum trichloride is supplemented into the ionic liquid and then reused, and neopentyl glycol regenerated through the hydrolysis reaction can also be recycled.

Preparation method of 2-(4-ethoxyphenyl)-2.2-dimethylethanol

The invention discloses a preparation method of 2-(4-ethoxyphenyl)-2.2-dimethylethanol. The preparation method comprises the following preparation steps: (1) dissolving one mole of acid in an alcoholsolvent, or in a mixed solvent consisting of the alcohol solvent and an ethers solvent; (2) heating the mixed solvent in step (1); and adding borohydride and metal salt; (3) continuing carrying out heat-insulation reaction, and recycling the alcohol solvent or the alcohol solvent or the ethers solvent under reduced pressure; and adding an organic solvent, dropwise adding hydrochloric acid while stirring to react, adding the organic solvent again, standing, layering and extracting; and drying an organic phase by using anhydrous sodium sulfate, and concentrating under reduced pressure to obtainthe product. Compared with the prior art, the method is high in safety, and the process is reasonable, simple and conveniently; and raw materials are easily obtained. The cost of the product is low, the quality is high, and the preparation method is environmentally friendly, and is suitable for industrial production; and the total yield of reaction taking 2-(4-ethoxyphenyl)-2.2-dimethylacetic acidcan reach 95% or above, and the content of the product reaches 98%.