83547-05-1

Basic information

• Product Name: 1-Piperazinehexanamide, 4-(3,4-dichlorophenyl)-N-(6-methoxy-4-methyl-8-quinolinyl)-
• CAS NO: 83547-05-1
• Molecular Formula: C27H32Cl2N4O2
• Molecular Weight: 515.483
• Mol File: 83547-05-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Piperazinehexanamide, 4-(3,4-dichlorophenyl)-N-(6-methoxy-4-methyl-8-quinolinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinehexanamide, 4-(3,4-dichlorophenyl)-N-(6-methoxy-4-methyl-8-quinolinyl)-(83547-05-1)
• EPA Substance Registry System: 1-Piperazinehexanamide, 4-(3,4-dichlorophenyl)-N-(6-methoxy-4-methyl-8-quinolinyl)-(83547-05-1)

Safety Data

• Hazardous Substances Data: 83547-05-1(Hazardous Substances Data)

Upstream product

• 22809-37-6 6-bromohexanoyl chloride 
• 57514-21-3 8-amino-6-methoxy-4-methylquinoline 
• 57260-67-0 1-(3,4-dichloro)phenylpiperazine 
• 75464-75-4 6-bromo-N-(6-methoxy-4-methyl-8-quinolinyl)-hexanamide 

Downstream Products

• 83546-76-3 N-[6-[4-(3,4-Dichlorophenyl)-1-piperazinyl]hexyl]-6-methoxy-4-methyl-8-quinolinamine 

Relevant articles and documents

Synthesis and antileishmanial activity of 6-methoxy-4-methyl-N-[6-(substituted-1-piperazinyl)hexyl]-8-quinolinami nes and related compounds

The 8-quinolinamine, 4-[6-[(6-methoxy-4-methyl-8-quinolinyl)amino]hexyl]-1-piperazineethanol (1b), has been shown to be highly effective against Leishmania donovani infections in hamsters. In an effort to obtain a more potent, less toxic 8-quinolinamine, a series of analogues (2) was prepared that examined particularly the structural requirements of the terminal of the terminal piperazine moiety. Of the substituted piperazines and alternative heterocycles prepared, as well as those quinoline analogues with ring insertion of a methyl group in the 2-position or an aryloxy substituent in the 5-position, an increase in potency was achieved only with the 2-hydroxypropyl analogue (2f).