83548-46-3

Basic information

• Product Name: METHYL N-BOC-L-PROLINE-4-ENE
• Synonyms: METHYL N-BOC-L-PROLINE-4-ENE ;(S)-2,3-Dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester;N-Boc-L-proline-4-ene Methyl Ester;(2S)-2,3-Dihydro-1H-pyrrole-1,2-dicarboxylic Acid 1-(1,1-DiMethylethyl) 2-Methyl Ester;(S)-2,3-Dihydro-1H-pyrrole-1,2-dicarboxylic Acid 1-(1,1-DiMethylethyl) 2-Methyl Ester;1-(tert-butyl) 2-methyl (S)-2,3-dihydro-1H-pyrrole-1,2-dicarboxylate;1H-Pyrrole-1,2-dicarboxylic acid, 2,3-dihydro-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S)-;(S)-1-tert-Butyl 2-methyl 2,3-dihydro-1H-pyrrole-1,2-dicarboxylate
• CAS NO: 83548-46-3
• Molecular Formula: C₁₁H₁₇NO₄
• Molecular Weight: 197.27406
• Product Categories: Amino Acids & Derivatives;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 83548-46-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 299.2°C at 760 mmHg
• Flash Point: 134.8°C
• Appearance: /
• Density: 1.148g/cm³
• Vapor Pressure: 0.00121mmHg at 25°C
• Refractive Index: 1.491
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL N-BOC-L-PROLINE-4-ENE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL N-BOC-L-PROLINE-4-ENE(83548-46-3)
• EPA Substance Registry System: METHYL N-BOC-L-PROLINE-4-ENE(83548-46-3)

Safety Data

• Hazardous Substances Data: 83548-46-3(Hazardous Substances Data)

Usage

Uses

N-Boc-L-proline-4-ene Methyl Ester is a L-proline derivative used in the preparation of intermediates for dipeptidyl peptidase (DPP) IV inhibitors

InChI:InChI=1/C11H17NO4/c1-11(2,3)16-10(14)12-7-5-6-8(12)9(13)15-4/h5,7-8H,6H2,1-4H3

Upstream product

• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 220405-40-3 2,2-difluoro-1,3-dimethyl-imidazolidine 
• 38078-09-0 diethylamino-sulfur trifluoride 
• 74844-92-1 (2S,4R)-4-Methylsulfanylthiocarboxyoxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 

Downstream Products

• 59936-29-7 (S)-N-(tert-butoxycarbonyl)proline methyl ester 
• 1109791-02-7 (1S,3S,5S)-2-tert-butyl 3-methyl 2-azabicyclo[3.1.0]hexane-2,3-dicarboxylate 
• 361440-67-7 [1S-(1α,3β,5α)]-3-(aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic acid 1,1-dimethylethyl ester 
• 709031-38-9 (5S)-5-aminocarbonyl-4,5-dihydro-1H-pyrrole-1-carboxylic acid 1-(1,1-dimethylethyl) ester 
• 1208008-34-7 (3S)-3-((tert-butyldiphenylsilyloxy)methyl)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane 
• 1419391-11-9 2-bromo-1-(4-bromophenyl)ethanone 
• 1419384-89-6 C₅₂H₆₂N₈O₆ 
• 1419387-39-5 C₁₉H₂₅BrN₄O₄ 
• 1612854-20-2 C₅₁H₅₈N₈O₉ 
• 1612854-18-8 C₅₄H₆₅N₉O₇ 
• 1612854-14-4 C₂₀H₂₅BrN₄O₅ 
• 1419391-16-4 2-bromo-1-(4-bromophenyl)ethanone 
• 1613083-77-4 C₅₀H₅₈N₈O₆ 
• 501096-43-1 C₁₈H₂₃NO₅ 

Relevant articles and documents

METHOD FOR PRODUCING FLUORINATED PROLINE DERIVATIVE

Disclosed is a method for efficiently producing a high-purity fluorinated proline derivative with high yield. Specifically disclosed is a method for producing a compound represented by the general formula (2) below wherein a compound represented by the formula (1) below is reacted with a fluorination agent, and then chlorine, bromine, iodine, hypochlorous acid, hypochlorite, hypobromous acid, hypobromite or N-halogenosuccinimide is caused to act on the reaction product obtained by the preceding reaction and containing the compound represented by the general formula (2) below and a by-product for chemically changing the by-product. (1) (In the formula (1), R1 represents an unsubstituted or substituted alkyl group having 1-6 carbon atoms or the like; R2 represents an unsubstituted or substituted alkyl group having 1-6 carbon atoms or the like; and R3 represents a hydroxyl group or the like.) (2) (In the formula (2), R1 and R2 are as defined above.)

Direktes Verfahren zur Synthese von N-Boc-L-3,4-Didehydroprolin

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