83553-60-0 Usage
General Description
4-(Methylthio)-1H-imidazole is an organic chemical compound with the formula C5H6N2S. It is a derivative of imidazole, a five-membered heterocyclic ring containing two nitrogen atoms. The "methylthio" group refers to the presence of a sulfur atom attached to a methyl group. 4-(Methylthio)-1H-imidazole is commonly used in organic synthesis as a building block for the preparation of a variety of pharmaceuticals, agrochemicals, and other fine chemicals. It is also employed as a reagent in chemical reaction to introduce the imidazole ring into other organic compounds. Additionally, it has been studied for its potential biological activities, including antioxidant, anti-inflammatory, and antimicrobial properties.
Check Digit Verification of cas no
The CAS Registry Mumber 83553-60-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,5,5 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 83553-60:
(7*8)+(6*3)+(5*5)+(4*5)+(3*3)+(2*6)+(1*0)=140
140 % 10 = 0
So 83553-60-0 is a valid CAS Registry Number.
InChI:InChI=1/C4H6N2S/c1-7-4-2-5-3-6-4/h2-3H,1H3,(H,5,6)
83553-60-0Relevant articles and documents
HIGH-YIELDING SYNTHESES OF 4(5)-SUBSTITUTED IMIDAZOLES VIA ORGANOLITHIUM INTERMEDIATES. THE UTILITY OF SULPHONAMIDE N-PROTECTION AND SILICON-CONTAINING BLOCKING GROUPS
Carpenter, Andrew J.,Chadwick, Derek J.
, p. 2351 - 2358 (2007/10/02)
N-protection of imidazole as its N,N-dimethyl-sulphonamido derivative, and blocking of the 2-position with the triethylsilyl group permits regioselective 5-metallation with sec-butyl-lithium.The resulting organolithium intermediates react with a range of electrophiles and the products are easily deprotected to give the 4(5)-substituted NH-free imidazoles in good to excellent yields.Isolation of the silicon-blocked intermediate is unnecessary and, indeed, is disadvantageous to final yields, making the procedure attractively economical of time.
