835629-63-5

Basic information

• Product Name: 1,2-bis(4-hydroxyphenyl)diselane
• Synonyms: 1,2-bis(4-hydroxyphenyl)diselane
• CAS NO: 835629-63-5
• Molecular Weight: 344.13
• Mol File: 835629-63-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2-bis(4-hydroxyphenyl)diselane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-bis(4-hydroxyphenyl)diselane(835629-63-5)
• EPA Substance Registry System: 1,2-bis(4-hydroxyphenyl)diselane(835629-63-5)

Safety Data

• Hazardous Substances Data: 835629-63-5(Hazardous Substances Data)

Upstream product

• 61629-31-0 acetic acid-(4-selenocyanato-phenyl ester) 
• 244047-83-4 4-Hydroxy-1-hydroseleno-benzol 
• 7722-84-1 dihydrogen peroxide 
• 106-41-2 4-bromo-phenol 
• 22216-66-6 bis(4-methoxyphenyl)selenide 
• 540-38-5 p-Iodophenol 

Downstream Products

• 858854-35-0 bis-(4-acetoxy-phenyl)-diselenide 

Relevant articles and documents

Rhodium-Catalyzed Enantioselective Hydroselenation of Heterobicyclic Alkenes

A highly efficient Rh(I)/(S)-xyl-Binap catalytic system is developed for the asymmetric hydroselenation of various nonpolar olefins with diselenides. Under these mild reaction conditions, a wide range of heterobicyclic alkenes give selenol-incorporated adducts in excellent enantioselectivities (up to 97%) along with high yields (up to 96%) by overcoming self-promoted racemic hydroselenation. The strategy is also applied for kinetic resolution of unsymmetric oxabenzonorbornadiene.

An investigation of in vitro cytotoxicity and apoptotic potential of aromatic diselenides

A target synthesis of a library of symmetric aromatic diselenides was attempted with the aim of generating anticancer lead compounds. Out of thirteen screened molecules (1-13) against a panel of human cancer cell lines, compound 8 exhibited highest cell growth inhibition in Human leukemia HL-60 cells with IC50 value of 8 μM. Compound 8 had a good pro-apoptotic potential as evidenced from several apoptotic protocols like DNA cell cycle analysis and monitoring of apoptotic bodies formation using phase contrast and nuclear microscopy with Hoechst 33,258. Also, 8 significantly inhibits S phase of the cell cycle and eventually trigger apoptosis in HL-60 cells through mitochondrial dependent pathway substantiated by the loss of mitochondrial potential. A theoretical investigation of DNA binding ability of 8 showed that it selectively bind to minor groove of DNA, where it is stabilized by hydrogen bonding and hydrophobic interactions.