83575-55-7Relevant articles and documents
The catalytic activity of Zn(II) and Mn(II) organometallic complexes
Mei, Luo,Yan, Li Xiao,Wei, Chen,Hai, Zhang Jia
, p. 2715 - 2721 (2013)
Zn(II) and Mn(II) organometallic complexes I and II were first used to catalyze the cyanosilylation reaction, and good catalytic results (24-99 %) were achieved. The catalytic activity of the complexes was determined by 1H NMR.
Application of an Electrochemical Microflow Reactor for Cyanosilylation: Machine Learning-Assisted Exploration of Suitable Reaction Conditions for Semi-Large-Scale Synthesis
Sato, Eisuke,Fujii, Mayu,Tanaka, Hiroki,Mitsudo, Koichi,Kondo, Masaru,Takizawa, Shinobu,Sasai, Hiroaki,Washio, Takeshi,Ishikawa, Kazunori,Suga, Seiji
supporting information, p. 16035 - 16044 (2021/09/02)
Cyanosilylation of carbonyl compounds provides protected cyanohydrins, which can be converted into many kinds of compounds such as amino alcohols, amides, esters, and carboxylic acids. In particular, the use of trimethylsilyl cyanide as the sole carbon source can avoid the need for more toxic inorganic cyanides. In this paper, we describe an electrochemically initiated cyanosilylation of carbonyl compounds and its application to a microflow reactor. Furthermore, to identify suitable reaction conditions, which reflect considerations beyond simply a high yield, we demonstrate machine learning-assisted optimization. Machine learning can be used to adjust the current and flow rate at the same time and identify the conditions needed to achieve the best productivity.
An uncoordinated tertiary nitrogen based tricarboxylate calcium network with Lewis acid-base dual catalytic sites for cyanosilylation of aldehydes
Wang, Ying-Xia,Wang, Hui-Min,Meng, Pan,Song, Dong-Xia,Hou, Juan-Juan,Zhang, Xian-Ming
, p. 1740 - 1745 (2021/02/16)
The design and utilization of dual sites for synergistic catalysts has been recognised as an efficient method towards high-efficiency catalysis in the cyanosilylation of aldehydes, which gives key intermediates for the synthesis of a number of valuable na