83636-46-8

Basic information

• Product Name: 2-(4-BroMo-phenyl)-propionic acid Methyl ester
• Synonyms: 2-(4-BroMo-phenyl)-propionic acid Methyl ester;methyl 2-(4-bromophenyl)propanoate;ethyl 2-(4-bromophenyl)propanoate
• CAS NO: 83636-46-8
• Molecular Formula: C₁₀H₁₁BrO₂
• Molecular Weight: 243.09714
• Mol File: 83636-46-8.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 280.2±15.0 °C(Predicted)
• Appearance: /
• Density: 1.383±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-(4-BroMo-phenyl)-propionic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-BroMo-phenyl)-propionic acid Methyl ester(83636-46-8)
• EPA Substance Registry System: 2-(4-BroMo-phenyl)-propionic acid Methyl ester(83636-46-8)

Safety Data

• Hazardous Substances Data: 83636-46-8(Hazardous Substances Data)

Usage

General Description

The chemical 2-(4-Bromo-phenyl)-propionic acid methyl ester, also known as bromfenac methyl ester, is a derivative of bromfenac, a non-steroidal anti-inflammatory drug (NSAID) commonly used as a potent inhibitor of cyclooxygenase (COX). This chemical compound is often utilized for its anti-inflammatory and analgesic properties, particularly in the treatment of various types of pain and inflammation, including postoperative ocular inflammation. Its methyl ester form enables it to be more easily metabolized in the body, allowing for faster and more effective delivery of the active ingredient. However, its usage should be carefully monitored and regulated due to potential side effects and interactions with other medications.

Upstream product

• 10342-83-3 4'-Bromopropiophenone 
• 108583-51-3 2-Hydroxy-4'-bromopropiophenone dimethylacetal 
• 67-56-1 methanol 
• 41841-16-1 (4-bromo-phenyl)-acetic acid methyl ester 
• 74-87-3 methylene chloride 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 201230-82-2 carbon monoxide 
• 42186-06-1 2-(4-Bromophenyl)propionitrile 
• 159755-11-0 1-bromo-4-(1-bromoethyl)benzene 
• 5391-88-8 1-(4-bromophenyl)ethanol 
• 99-90-1 para-bromoacetophenone 
• 53086-53-6 2-(4-bromophenyl)propionic acid 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 236747-81-2 Methyl 2-[4-(5-bromo-pyridin-3-yl)phenyl]propanoate 
• 154825-97-5 methyl 2-(4-bromophenyl)-2,2-dimethylacetate 
• 1428526-57-1 methyl 2-(4-(diethoxyphosphoryl)phenyl)propanoate 
• 1428526-58-2 2-(4-(diethoxyphosphoryl)phenyl)propanoic acid 
• 1428526-59-3 diethyl 4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidin-5-ylamino)-1-oxopropan-2-yl)phenylphosphonate 
• 1428526-68-4 diethyl 4-(1-(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-ylamino)-1-oxopropan-2-yl)phenylphosphonate 
• 53716-49-7 2-(6-chloro-carbazol-2-yl)-propionic acid 
• 125670-62-4 α-methyl-4-cyanobenzeneacetic acid methyl ester 

Relevant articles and documents

Asymmetric Aminations and Kinetic Resolution of Acyclic α-Branched Ynones

An efficient method for asymmetric synthesis of acyclic α-tertiary amine derivatives has been achieved through enantioselective aminations of α-branched ynones with azodicarboxylates enabled by chiral phosphoric acid catalysis. Moreover, kinetic resolution of racemic starting material was realized under these conditions, which gave access to valuable enantioenriched α-substituted ketones. A wide array of α-aryl and alkyl-substitutions, and the substituted alkynyl groups were well compatible with this method, producing both the amination products and the recovered ketones with good to high enantioselectivities.

A general platinum-catalyzed alkoxycarbonylation of olefins

Hydroxy- and alkoxycarbonylation reactions constitute important industrial processes in homogeneous catalysis. Nowadays, palladium complexes constitute state-of-the-art catalysts for these transformations. Herein, we report the first efficient platinum-catalysed alkoxycarbonylations of olefins including sterically hindered and functionalized ones. This atom-efficient catalytic transformation provides straightforward access to a variety of valuable esters in good to excellent yields and often with high selectivities. In kinetic experiments the activities of Pd- and Pt-based catalysts were compared. Even at low catalyst loading, Pt shows high catalytic activity.

COMPOUNDS AND METHODS FOR TREATMENT OF HEDGEHOG PATHWAY ASSOCIATED CONDITIONS

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