83706-50-7

Basic information

• Product Name: 1-(4-FLUOROPHENYL)CYCLOPENTANECARBONITRILE
• Synonyms: 1-(4-FLUOROPHENYL)CYCLOPENTANECARBONITRILE;LABOTEST-BB LT00441194;1-(4-Fluorophenyl)cyclopentanecarbonitrile,99%;1-(4-Fluorophenyl)cyclopentanecarbonitrile, 99% 5GR
• CAS NO: 83706-50-7
• Molecular Formula: C₁₂H₁₂FN
• Molecular Weight: 189.23
• EINECS: 280-526-7
• Mol File: 83706-50-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 303.5 °C at 760 mmHg
• Flash Point: 129.5 °C
• Appearance: Clear slightly yellow/Liquid
• Density: 1.0913 (estimate)
• Vapor Pressure: 0.000929mmHg at 25°C
• Refractive Index: 1.514-1.516
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(4-FLUOROPHENYL)CYCLOPENTANECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUOROPHENYL)CYCLOPENTANECARBONITRILE(83706-50-7)
• EPA Substance Registry System: 1-(4-FLUOROPHENYL)CYCLOPENTANECARBONITRILE(83706-50-7)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 36/37/39-26
• RIDADR: 3276
• Hazardous Substances Data: 83706-50-7(Hazardous Substances Data)

Usage

Chemical Properties

clear slightly yellow liquid

InChI:InChI=1/C12H12FN/c13-11-5-3-10(4-6-11)12(9-14)7-1-2-8-12/h3-6H,1-2,7-8H2

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 459-22-3 4-fluorophenylacetonitrile 

Downstream Products

• 1338349-08-8 1-benzyl-N-{[1-(4-fluorophenyl)cyclopentyl]methyl}piperidine-4-carboxamide hydrochloride 
• 75180-50-6 (1-(4-fluorophenyl)cyclopentyl)methanamine 
• 1338349-00-0 tert-butyl 4-({[1-(4-fluorophenyl)cyclopentyl]methyl}carbamoyl)piperidine-1-carboxylate 
• 1356862-09-3 benzyl [1-(4-fluorophenyl)cyclopentyl]carbamate 
• 1356861-76-1 benzyl 4-{[1-(4-fluorophenyl)cyclopentyl]carbamoyl}piperidine-1-carboxylate 
• 1356861-77-2 N-[1-(4-fluorophenyl)cyclopentyl]-1-(2-phenylethyl)piperidine-4-carboxamide 
• 1356862-10-6 N-[1-(4-fluorophenyl)cyclopentyl]piperidine-4-carboxamide 
• 1356861-78-3 N-[1-(4-fluorophenyl)cyclopentyl]-1-(2-phenylethyl)piperidine-4-carboxamide fumarate 
• 214262-99-4 1-(4-fluorophenyl)-1-cyclopentanecarboxylic acid 

Relevant articles and documents

Amide compound and derivative thereof, preparation method, pharmaceutical composition and application thereof

The invention discloses an amide compound and derivative thereof, a preparation method, a pharmaceutical composition and application thereof. The structure of the amide compound is shown as a formula (I). The derivatives of theamide compound relate to a stereoisomer, a tautomer, a metabolite, a metabolic precursor, a prodrug, a solvate, a salt of the solvate, a crystal, a pharmaceutically acceptable salt or a mixture of the above of theamide compound. The amide compound and the derivative thereof have an efficient inhibition effect on indoleamine 2, 3-dioxygenase 1, and can be used for preparing medicines for treating indoleamine 2, 3-dioxygenase 1 mediated immunosuppression related diseases, the prepared medicine can exert the medicine effect at the molecular level and is wide in application, and the synthesis method of the compound is simple, convenient and easy to operate.

INHIBITOR OF INDOLEAMINE-2,3-DIOXYGENASE (IDO)

The present disclosure provides compounds of Formula (I). The compounds described herein may be useful in treating a disease associated with IDO, for example, cancer or an infectious disease (e.g., viral or bacterial infectious diseases). Also, provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.

Synthesis and pharmacological evaluation of 1-alkyl-N-[2-ethyl-2-(4- fluorophenyl)butyl]piperidine-4-carboxamide derivatives as novel antihypertensive agents

We synthesized and evaluated inhibitory activity against T-type Ca 2+ channels for a series of 1-alkyl-N-[2-ethyl-2-(4-fluorophenyl) butyl]piperidine-4-carboxamide derivatives. Structure-activity relationship studies have revealed that dialkyl substituents at the benzylic position play an important role in increasing inhibitory activity. Oral administration of N-[2-ethyl-2-(4-fluorophenyl)butyl]-1-(2-phenylethyl)piperidine-4-carboxamide (20d) lowered blood pressure in spontaneously hypertensive rats without inducing reflex tachycardia, which is often caused by traditional L-type Ca2+ channel blockers.