837392-65-1

Basic information

• Product Name: 1,2-BENZISOXAZOLE, 5-BROMO-
• Synonyms: 1,2-BENZISOXAZOLE, 5-BROMO-;5-BROMOBENZO[D]ISOXAZOLE;5-BROMO-1,2-BENZISOXAZOLE;5-broMo-1,2-benzoxazole
• CAS NO: 837392-65-1
• Molecular Formula: C7H4BrNO
• Molecular Weight: 198.02
• Mol File: 837392-65-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 276.122 °C at 760 mmHg
• Flash Point: 120.794 °C
• Appearance: /
• Density: 1.711 g/cm³
• Storage Temp.: 2-8°C
• PKA: -3.82±0.30(Predicted)
• CAS DataBase Reference: 1,2-BENZISOXAZOLE, 5-BROMO-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-BENZISOXAZOLE, 5-BROMO-(837392-65-1)
• EPA Substance Registry System: 1,2-BENZISOXAZOLE, 5-BROMO-(837392-65-1)

Safety Data

• Hazardous Substances Data: 837392-65-1(Hazardous Substances Data)

Usage

General Description

1,2-Benzisoxazole, 5-bromo- is a chemical compound with the formula C7H4BrNO. It is a brominated derivative of benzisoxazole, and is mainly used in research and development. The compound has potential applications in the pharmaceutical industry, particularly in the synthesis of new pharmaceutical agents and drug candidates. It is also used as a building block in the preparation of various organic molecules and is an important intermediate in organic synthesis. Additionally, 1,2-Benzisoxazole, 5-bromo- may have other uses in academic and industrial research, such as in the study of chemical reactions and mechanisms.

Upstream product

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Relevant articles and documents

An efficient synthesis of oxazolines: Via a cascade reaction between azaoxyallyl cations and 1,2-benzisoxazoles

A formal [3 + 2] cycloaddition reaction between the C and O terminals of azaoxyallyl cations formed in situ and 1,2-benzisoxazoles has been realized. This one-pot cycloaddition method provided an effective and practical pathway to synthesize oxazoline in good yields under mild conditions. The title products exhibited unique fluorescence properties.

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

Triflic anhydride: A mild reagent for highly efficient synthesis of 1,2-benzisoxazoles, isoxazolo, and isothiazolo quinolines without additive or base

The synthetic utility of trifluoromethanesulphonic anhydride (triflic anhydride, TA) without additive or base for the high-yielding synthesis of a wide variety of 1,2-benzisoxazoles from 2-hydroxyaryl aldoximes and ketoximes under mild conditions has been carried out for the first time. As a continuation of our study, syntheses of isoxazolo and isothiazolo quinolones have also been demonstrated using triflic anhydride under similar conditions. This method is simple and has benefits from the easy way to isolate the products in excellent yields.