83764-65-2

Basic information

• Product Name: Piperaquine
• Synonyms: Piperaquine;Brn 0905079;Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro- (9ci);Quinoline, 4,4'-(trimethylenedi-4,1-piperazinediyl)bis(7-chloro-
• CAS NO: 83764-65-2
• Molecular Formula: C29H32Cl2N6
• Molecular Weight: 535.51058
• Mol File: 83764-65-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Piperaquine(CAS DataBase Reference)
• NIST Chemistry Reference: Piperaquine(83764-65-2)
• EPA Substance Registry System: Piperaquine(83764-65-2)

Safety Data

• Hazardous Substances Data: 83764-65-2(Hazardous Substances Data)

Usage

Pharmaceutical Applications

A bisquinoline used to treat malaria in China since 1978. It is structurally related to chloroquine, but active against chloroquine- resistant P. falciparum. A combination with dihdyroartemisinin has shown excellent tolerability and high cure rates for multidrug-resistant falciparum malaria. It is highly lipid-soluble and orally well absorbed. The elimination half-life is 20–30 days and there is extensive metabolism. Adverse effects are similar to chloroquine, but pruritus is uncommon.

Upstream product

• 109-64-8 1,3-dibromo-propane 
• 837-52-5 7-chloro-4-piperazinylquinoline 
• 86-98-6 4,7-dichloroquinoline 

Downstream Products

• 85547-56-4 Piperaquine tetraphosphate 
• 915967-82-7 1,3-bis[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propanephosphate 

Relevant articles and documents

AN IMPROVED PROCESS FOR THE PREPARATION OF PIPERAQUINE

The present invention relates to an improved process for the preparation of 7-chloro- 4-piperazin-1-yl-quinoline of formula (I), a key intermediate for the synthesis of Piperaquine or its pharmaceutically acceptable salts.