83784-21-8Relevant articles and documents
Novel heterocyclic esters of benzopyranopyridines
-
, (2008/06/13)
Novel heterocyclic esters of benzopyranopyridines represented by the formula STR1 wherein R1 is hydrogen, lower alkyl, lower alkanoyl, cycloalkyl-lower alkyl, cycloalkyl-lower alkanoyl, lower alkenyl, lower alkynyl, halo-loweralkenyl, phenyl-lower alkyl, phenyl-lower alkenyl or phenyl-lower alkynyl; R2 is lower alkyl; R3 is an alkyl having one to twenty carbon atoms or a cycloalkyl-lower alkyl, Y is a straight or branched chain alkylene having one to eight carbon atoms, and R4 is a group of the formula STR2 a is an integer from 1 to 4, b is an integer from 1 to 4 and X is CH2, O, S or N--R5 with R5 being hydrogen or lower alkyl, with the limitation that when X is O, S or N--R5, a and b each must be 2 and R6 is hydrogen or a lower alkyl group bonded to a carbon in the ring; and the acid addition salts thereof.
Drugs derived from cannabinoids. 2. Basic esters of nitrogen and carbocyclic analogs
Razdan,Terris,Pars,Plotnikoff,Dodge,Dren,Kyncl,Somani
, p. 454 - 461 (2007/10/04)
Various basic esters of nitrogen (2) and carbocyclic (3 and 4) analogs of cannabinoids were synthesized using dicyclohexylcarbodiimide in methylene chloride. The compounds in the three series were studied in selected pharmacological tests in mice, rats, dogs, and cats. It was shown that making the basic ester from the phenol retains biological activity and can lead to a greater selectivity of action, particularly the antinociceptive activity. The most interesting esters were 5, 6, 10, and 14 in the nitrogen analogs series and 19 and 20 in the carbocyclic series. Compound 5 was more potent than codeine in the writhing, hot plate, and tail flick tests and is at present undergoing clinical testing. Compound 20 was very potent in the mouse audiogenic seizure test and is of interest as an anticonvulsant agent.
