839714-33-9

Basic information

• Product Name: 1-Isopropylpyrazole-5-boronic Acid
• Synonyms: 1-Isopropylpyrazole-5-boronic Acid;1-isopropyl-1H-pyrazol-5-ylboronic acid;1-Isopropyl-1H-pyrazole-5-boronic acid;Boronic acid, [1-(1-methylethyl)-1H-pyrazol-5-yl]-
• CAS NO: 839714-33-9
• Molecular Formula: C₆H₁₁BN₂O₂
• Molecular Weight: 153.97474
• Mol File: 839714-33-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 1-Isopropylpyrazole-5-boronic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Isopropylpyrazole-5-boronic Acid(839714-33-9)
• EPA Substance Registry System: 1-Isopropylpyrazole-5-boronic Acid(839714-33-9)

Safety Data

• Hazardous Substances Data: 839714-33-9(Hazardous Substances Data)

Usage

General Description

1-Isopropylpyrazole-5-boronic acid is a chemical compound that belongs to the class of boronic acid derivatives. It is used in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. 1-Isopropylpyrazole-5-boronic Acid is a versatile building block in the formation of carbon-carbon and carbon-heteroatom bonds, making it valuable in the creation of complex organic molecules. Its boronic acid functionality allows it to participate in Suzuki-Miyaura cross-coupling reactions, which are widely employed in the synthesis of biaryl compounds. Overall, 1-Isopropylpyrazole-5-boronic acid plays a crucial role in the production of various important compounds, contributing to advancements in the fields of medicine and agriculture.

Upstream product

• 688-74-4 boric acid tributyl ester 
• 18952-87-9 1-isopropyl-1H-pyrazole 

Downstream Products

• 839714-34-0 1-isopropyl-5-(2-methoxy-5-nitrophenyl)-1H-pyrazole 
• 1162644-60-1 2'-fluoro-5-(2-isopropyl-2H-pyrazol-3-yl)-4'-methyl-biphenyl-3-carboxylic acid methyl ester 
• 839714-36-2 4-chloro-1-isopropyl-5-(2-methoxy-5-nitro-phenyl)-1H-pyrazole 
• 839714-32-8 4-bromo-1-isopropyl-5-(2-methoxy-5-nitrophenyl)-1H-pyrazole 
• 839714-31-7 3-(4-bromo-2-isopropyl-2H-pyrazol-3-yl)-4-methoxyphenylamine 
• 839714-35-1 3-(4-chloro-2-isopropyl-2H-pyrazol-3-yl)-4-methoxy-phenylamine 
• 839714-37-3 3-(2-isopropyl-2H-pyrazol-3-yl)-4-methoxy-phenylamine 

Relevant articles and documents

Discovery of 1-[3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxyphenyl]-3-(2, 4-difluorophenyl)urea (Nelotanserin) and Related 5-Hydroxytryptamine 2A Inverse Agonists for the Treatment of Insomnia

Insomnia affects a growing portion of the adult population in the U.S. Most current therapeutic approaches to insomnia primarily address sleep onset latency. Through the 5-hydroxytryptamine2A (5-HT2A) receptor, serotonin (5-HT) plays a role in the regulation of sleep architecture, and antagonists/ inverse-agonists of 5-HT2A have been shown to enhance slow wave sleep (SWS). We describe here a series of 5-HT2A inverse-agonists that when dosed in rats, both consolidate the stages of NREM sleep, resulting in fewer awakenings, and increase a physiological measure of sleep intensity. These studies resulted in the discovery of 1-[3-(4-bromo-2- methyl-2i/-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (Nelotanserin), a potent inverse-agonist of 5-HT2A that was advanced into clinical trials for the treatment of insomnia.

DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERTO

The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to