84315-23-1

Basic information

• Product Name: 3,5-DIFLUOROCINNAMIC ACID
• Synonyms: (2E)-3-(3,5-DIFLUOROPHENYL)ACRYLIC ACID;RARECHEM BK HW 0255;TIMTEC-BB SBB006675;(2E)-3-(3,5-Difluorophenyl)-2-propenoic acid;3-(3,5-Difluorophenyl)propenoic acid;3,5-Difluorocinnamic acid,98%;(E)-3-(3,5-difluorophenyl)acrylic acid
• CAS NO: 84315-23-1
• Molecular Formula: C₉H₆F₂O₂
• Molecular Weight: 184.14
• Product Categories: Fluoro-contained cinnamic acid series;Cinnamic acid;Miscellaneous
• Mol File: 84315-23-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 204-205 °C(lit.)
• Boiling Point: 272 °C at 760 mmHg
• Flash Point: 118.3 °C
• Appearance: White to off-white/Fluffy Shiny Powder or Needles
• Density: 1.3056 (estimate)
• Vapor Pressure: 0.00306mmHg at 25°C
• BRN: 6194926
• CAS DataBase Reference: 3,5-DIFLUOROCINNAMIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIFLUOROCINNAMIC ACID(84315-23-1)
• EPA Substance Registry System: 3,5-DIFLUOROCINNAMIC ACID(84315-23-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-26/37/39-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 84315-23-1(Hazardous Substances Data)

Usage

Chemical Properties

white to off-white fluffy shiny powder or needles

InChI:InChI=1/C9H6F2O2/c10-7-3-6(1-2-9(12)13)4-8(11)5-7/h1-5H,(H,12,13)/p-1/b2-1+

Upstream product

• 461-96-1 3,5-difluorobromobenzene 
• 110-89-4 piperidine 
• 32085-88-4 3,5-difluorobenzaldehyde 
• 141-82-2 malonic acid 
• 79-10-7 acrylic acid 
• 73183-34-3 bis(pinacol)diborane 
• 151361-87-4 1-ethynyl-3,5-difluorobenzene 
• 101471-20-9 2-bromo-4,6-difluoroaniline hydrobromide 
• 367-25-9 2,4-difluorophenylamine 
• 64248-63-1 3,5-difluorobenzonitrile 

Downstream Products

• 695187-53-2 (E)‐3‐(3,5‐difluorophenyl)acryloyl chloride 
• 207462-72-4 3-(3,5-difluorophenyl)propanal 
• 211568-08-0 (E)-3-(3,5-difluorophenyl)acryloyl azide 
• 1352485-19-8 R,S-2-[4-(1H-indol-3-yl)-trans-cyclohexylamino]-2-[1-(trans-3,5-difluorocinnamoyl)piperidin-4-yl]-acetamide 

Relevant articles and documents

Synthetic method of 7-fluoro-5-hydroxy-2,3-dihydro-1hydrogen-indene-1-one

The invention relates to a synthetic method of 7-fluoro-5-hydroxy-2,3-dihydro-1hydrogen-indene-1-one. The technical problem that there is no synthetic method suitable for industrialization at present is mainly solved. The synthetic method of the invention

Synthesis and mesomorphic properties of tolane-based fluorinated liquid crystals with an acrylate linkage

Six series of tolane-based fluorinated liquid crystals containing an acrylate linker were synthesized and their mesomorphic properties were characterized. The compounds generally exhibit SmA and N phases in wide temperature ranges. The introduction of acrylate linkers increases the clearing points by 20°C-30°C and suppresses the formation of higher ordered monotropic SmB phases. para-Fluorination is favorable for the mesophase stability, whereas meta-fluorination is not. The introduction of a 2,3,5,6-tetrafluorophenylene group decreases the clearing points and also suppresses the formation of the monotropic SmB phase. Copyright Taylor & Francis Group, LLC.

4-Aralkyl-5-substituted-1,2,4-triazole-5-thiols

Compounds of formula (I) and pharmaceutically acceptable salts thereof are described in which, n is 0 to 5; X1 to X5 are any accessible combination of hydrogen, halogen, C1 6alkyl, C1 6alkoxy, cyano, nitro, SONH2, SO2NH2, SO2CH3, SO2CH2F, SO2CHF2, SO2CF3, CF3, CHO, OH, CH2OH, CO2H, or CO2CpH2p+1wherein p is 1 to 4; R1 is phenyl substituted by X1 to X5, C1 4alkyl, C3 6cycloalkyl, or an arylC1 4alkyl group substituted by X1 to X5; R2 is hydrogen, C1 4alkyl or (CH2)m-CO2R3; m is 0 to 5; and R3 is H or C1 4alkyl. These compounds are dopamine-β-hydroxylase inhibitors. Pharmaceutical compositions are described as are methods of use. Processes for the preparation of these compounds are described.