84359-11-5

Basic information

• Product Name: 2-METHYLAMINOPYRIDINE DIHYDROCHLORIDE
• Synonyms: piperidin-2-ylMethanaMine hydrochloride;pyridin-2-ylmethanamine hydrochloride;FTQQURYZPUHQND-QPMNBSDMSA-N
• CAS NO: 84359-11-5
• Molecular Formula: C₆H₈N₂*2ClH
• Molecular Weight: 0
• Mol File: 84359-11-5.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-METHYLAMINOPYRIDINE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLAMINOPYRIDINE DIHYDROCHLORIDE(84359-11-5)
• EPA Substance Registry System: 2-METHYLAMINOPYRIDINE DIHYDROCHLORIDE(84359-11-5)

Safety Data

• Hazardous Substances Data: 84359-11-5(Hazardous Substances Data)

Usage

General Description

2-Methylaminopyridine dihydrochloride is a chemical compound and a salt consisting of a pyridine derivative with a methylamino group, combined with two molecules of hydrochloric acid. It is commonly used as a reagent in chemical synthesis and as a building block in the pharmaceutical industry for the production of various drugs and active pharmaceutical ingredients. The compound is soluble in water and organic solvents, and its properties make it suitable for a wide range of applications, including in the production of dyes, pesticides, and other specialty chemicals. It is important to handle and store 2-Methylaminopyridine dihydrochloride with care, as it is corrosive and can cause irritation to the skin, eyes, and respiratory system upon exposure.

Upstream product

• 3731-51-9 2-(Aminomethyl)pyridine 
• 4857-06-1 2-chloro-1H-benzoimidazole 
• 100-70-9 2-Cyanopyridine 
• 3243-07-0 2-(nitromethyl)pyridine 
• 1121-60-4 pyridine-2-carbaldehyde 
• 2110-14-7 2-hydroxyiminomethyl-pyridine 

Downstream Products

• 62402-24-8 ethyl [(pyridin-2-ylmethyl)amino]acetate 
• 127872-13-3 N¹-<(pyrid-2-yl)methyl>-4-<(1,4,8,11-tetraazacyclotetradec-1-yl)methyl>benzamide pentahydrochloride 
• 1257425-08-3 4-(4-methoxyphenyl)-3-(pyridine-2-ylmethyl)thiazol-2(3H)imine 
• 1257425-07-2 3-(pyridine-2-ylmethyl)-4-p-tolylthiazol-2(3H)imine 
• 1257425-06-1 4-phenyl-3-(pyridine-2-ylmethyl)thiazol-2(3H)imine 

Relevant articles and documents

Fabrication of ω-Transaminase@Metal-Organic Framework Biocomposites for Efficiently Synthesizing Benzylamines and Pyridylmethylamines

In this study, ten ω-transaminases (ω-TAs) have been investigated to efficiently catalyze the synthesis of twenty-four functionalized benzylamines and pyridylmethylamines. We optimized the reactions, screened suitable amino donors and compared ω-transaminases activities for all aromatic aldehyde substrates. Under the optimized conditions, eighteen aromatic amines have been obtained with 60.4%–96.6% conversions and isolated only via simple extraction and recrystallization with 18.5%–81% yields on a preparative scale. Furthermore, we first immobilized the Bm-STA onto the MOFs via the physical adsorption to overcome the limitation of free enzyme and improve their industrial applications. The obtained Bm-STA/UiO-66-NH2 composites exhibited not only high enzymes loading (80.4 mg g?1) and enzyme activity recovery (95.8%), but also the better reusability, storage stability, pH stability and the tolerance to acetone and DMF.

Metal-Free Synthesis of Heteroaryl Amines or Their Hydrochlorides via an External-Base-Free and Solvent-Free C-N Coupling Protocol

Herein, a metal-free and solvent-free protocol was developed for the C-N coupling of heteroaryl halides and amines, which afforded numerous heteroaryl amines or their hydrochlorides without any external base. Further investigations elucidated that the basicity of amines and specific interactions derived from the X-ray crystallography analysis of 3j′·HCl played pivotal roles in the reactions. Moreover, this protocol was scalable to gram scales and applicable to drug molecules, which demonstrated its practical value for further applications.

Synthesis, intermolecular interactions and biological activities of two new organic-inorganic hybrids C6H10N2,2Br and C6H10N2,2Cl·H2O

A slow evaporation method has permitted the crystallization of two novel crystals of (2-aminomethyl)pyridindiumdihalide C6H10N2,2Br (1) and C6H10N2,2Cl·H2O (2). The structures of the prepared compounds (1) and (2) were elucidated by single-crystal X-ray diffraction which revealed that they crystallize, respectively, with triclinic and monoclinic symmetries. Their crystal packing was stabilized by non-covalent interactions, including N-H?Br, C-H?Br, N-H?Cl, O-H?Cl and N-H?O hydrogen bonds. 3-D Hirshfeld surface analysis followed by 2-D fingerprint schemes gives insights into the intermolecular interactions in the crystalline structure. Furthermore, the FT-IR spectroscopy of these two compounds was carried out. The synthesized products were also screened for in vitro antioxidant and antimicrobial activities, which reveals their favourable antioxidant activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) as well as the discolouration of β-carotene.