844639-57-2

Basic information

• Product Name: (+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID
• Synonyms: TM30089;9H-Carbazole-9-acetic acid, 3-[[(4-fluorophenyl)sulfonyl]MethylaMino]-1,2,3,4-tetrahydro-
• CAS NO: 844639-57-2
• Molecular Formula: C21H21FN2O4S
• Molecular Weight: 416.47
• Mol File: 844639-57-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 165-173℃ (dichloromethane )
• Boiling Point: 639.1±65.0 °C(Predicted)
• Appearance: /
• Density: 1.41±0.1 g/cm3(Predicted)
• PKA: 4.33±0.10(Predicted)
• CAS DataBase Reference: (+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID(844639-57-2)
• EPA Substance Registry System: (+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID(844639-57-2)

Safety Data

• Hazardous Substances Data: 844639-57-2(Hazardous Substances Data)

Usage

General Description

(+)-3-[[(4-FLUOROPHENYL)SULFONYL]METHYLAMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-ACETIC ACID, also known as Carvedilol, is a medication used to treat heart failure and hypertension. It belongs to a class of drugs called beta-blockers, which work by relaxing blood vessels and slowing the heart rate to improve blood flow and decrease blood pressure. The chemical structure of Carvedilol includes a tetrahydrocarbazole ring system, a fluorophenylsulfonyl group, and an acetic acid moiety, all of which contribute to its pharmacological activity. Carvedilol is known to have antioxidant and anti-inflammatory properties, and it is also used in the management of angina and arrhythmias. It is typically administered orally and is available in various formulations, including immediate-release and extended-release tablets.

Upstream product

• 844639-50-5 ethyl (3-oxo-1,2,3,4-tetrahydrocarbazol-9-yl)acetate glycol ketal 
• 844639-53-8 (±)-ethyl 2-(3-(methylamino)-1,2,3,4-tetrahydro-9H-carbazol-9-yl)acetate 
• 844639-51-6 ethyl (3-oxo-1,2,3,4-tetrahydrocarbazol-9-yl)acetate 
• 54621-12-4 1,2,4,9-tetrahydrospiro[3H-carbazole-3,2*-[1,3]doxolane] 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 844639-55-0 ethyl {3-[(4-fluorobenzenesulfonyl)methylamino]-1,2,3,4-tetrahydrocarbazol-9-yl}acetate 

Relevant articles and documents

COMPOUND EXHIBITING PGD 2 RECEPTOR ANTAGONISM

A compound having CRTH2 receptor antagonism, represented by the following formula (I). The compound is useful for the treatment of allergic diseases having a relation to eosinophils and the like. A compound of the formula (I): wherein a group represented