84504-69-8 Usage
Description
Irsogladine is a gastroprotective agent. It increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC). Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME . It also inhibits superoxide anion production induced by fMLP and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram .
Chemical Properties
White Solid
Uses
Different sources of media describe the Uses of 84504-69-8 differently. You can refer to the following data:
1. An anti-ulcer drug.
2. antiulcerative;selective PDE4 inhibitor which also enhances gap junction intercellular communication
Biological Activity
Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.
Check Digit Verification of cas no
The CAS Registry Mumber 84504-69-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,5,0 and 4 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 84504-69:
(7*8)+(6*4)+(5*5)+(4*0)+(3*4)+(2*6)+(1*9)=138
138 % 10 = 8
So 84504-69-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H7Cl2N5.C4H4O4/c10-4-1-2-6(11)5(3-4)7-14-8(12)16-9(13)15-7;5-3(6)1-2-4(7)8/h1-3H,(H4,12,13,14,15,16);1-2H,(H,5,6)(H,7,8)/b;2-1-
84504-69-8Relevant articles and documents
Irsogladine maleate preparation method
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Paragraph 0009; 0010, (2019/05/16)
The invention belongs to the field of organic matter synthesis, and particularly relates to an irsogladine maleate preparation method, wherein p-dichlorobenzene is used as a starting raw material, andfive reactions of acetylation, bromoform reaction, cyanation, cyclization and salt formation are performed to prepare the target compound. According to the present invention, the new irsogladine maleate preparation method is used, can significantly accelerate the reaction rate and improve the yield, has advantages of cost reducing, environment protection, simple operation and convenient post-treatment, and is suitable for industrial production.