845273-93-0 Usage
Description
Sevelamer carbonate (SC) is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion. SC has been found to have the same safety and efficacy profile as Sevelamer HCl in HD patients.Sevelamer carbonate(Renvela) is a nonaluminum, non-calcium-basedphosphorus binder that traps phosphorus in the bowel through ion exchange and hydrogen binding. This drug replaced sevelamer hydrochloride(Renagel) and has an advantage of not generating an acid load, as its precursor, sevelamer hydrochloride, did. It also has the advantage of lowering LDL cholesterol due to gut binding of bile acids.
Uses
Different sources of media describe the Uses of 845273-93-0 differently. You can refer to the following data:
1. Sevelamer Carbonate, a non-?absorbed polymer is an oral phosphate binder in patients with kidney failure. It is reported that Sevelamer Carbonate is less likely to cause hypercalcemia, low levels of PTH, and progressive coronary and aortic calcification in hemodialysis patients than calcium-?based phosphate binders.
2. Control of serum phosphorus in patients with chronic kidney disease (phosphate binder).
Check Digit Verification of cas no
The CAS Registry Mumber 845273-93-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,5,2,7 and 3 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 845273-93:
(8*8)+(7*4)+(6*5)+(5*2)+(4*7)+(3*3)+(2*9)+(1*3)=190
190 % 10 = 0
So 845273-93-0 is a valid CAS Registry Number.
InChI:InChI=1/C3H5ClO.C3H7N.CH2O3/c4-1-3-2-5-3;1-2-3-4;2-1(3)4/h3H,1-2H2;2H,1,3-4H2;(H2,2,3,4)
