845866-82-2

Basic information

• Product Name: 1-Bromo-2-difluoromethylbenzene
• Synonyms: 1-Bromo-2-(difluoromethyl)benzene, 2-Bromo-alpha,alpha-difluorotoluene;2-Bromobenzal fluoride;2-Bromo-1-(difluoromethyl)benzene
• CAS NO: 845866-82-2
• Molecular Formula: C₇H₅BrF₂
• Molecular Weight: 207.02
• Mol File: 845866-82-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 197.2°C at 760 mmHg
• Flash Point: 82℃
• Appearance: Clear colorless/Liquid
• Density: 1.597 g/mL at 25 °C
• Vapor Pressure: 0.539mmHg at 25°C
• Refractive Index: n20/D1.514
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 1-Bromo-2-difluoromethylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-2-difluoromethylbenzene(845866-82-2)
• EPA Substance Registry System: 1-Bromo-2-difluoromethylbenzene(845866-82-2)

Safety Data

• Hazard Codes: Xi,N
• Statements: 36/37/38-51/53
• Safety Statements: 26-61
• HazardClass: IRRITANT
• Hazardous Substances Data: 845866-82-2(Hazardous Substances Data)

Usage

General Description

1-Bromo-2-difluoromethylbenzene, also known as 2-Bromo-1-(difluoromethyl)benzene, is a chemical compound with the molecular formula C7H5BrF2. It is a colorless liquid and is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. 1-Bromo-2-difluoromethylbenzene is commonly produced through the halogen exchange reaction and can also be used as a building block in the production of various polymers and materials. It is important to handle and store 1-Bromo-2-difluoromethylbenzene with caution, as it is a hazardous substance that can cause health and environmental risks if mishandled.

InChI:InChI=1/C7H5BrF2/c8-6-4-2-1-3-5(6)7(9)10/h1-4,7H

Upstream product

• 583-55-1 1-Bromo-2-iodobenzene 
• 667-27-6 Ethyl bromodifluoroacetate 
• 244205-40-1 (2-bromophenyl)boronic acid 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 879275-72-6 2-[2-(difluoromethyl)-phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1182357-10-3 1-(chloromethyl)-2-(difluoromethyl)benzene 
• 1018678-50-6 2-(difluoromethyl)benzaldehyde 

Relevant articles and documents

Base-Catalyzed H/D Exchange Reaction of Difluoromethylarenes

The budding deuteriodifluoromethyl group (CF2D) is a potentially significant functional group in medicinal chemistry. Herein, we investigated t-BuOK-catalyzed H/D exchange reaction of difluoromethylarenes in DMSO-d6 solution. The method provides excellent

SUBSTITUTED BENZOTHIOPHENE ANALOGS AS SELECTIVE ESTROGEN RECEPTOR DEGRADERS

In one aspect, the disclosure relates to relates to substituted benzothiophene analogs which are useful as selective degraders of estrogen receptor, methods of making same, pharmaceutical compositions comprising same, and methods of treating one or more clinical conditions associated with estrogen receptor, such as a cancer, including breast cancer, or osteoporosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Copper-Catalyzed Difluoromethylation of Aryl Iodides with (Difluoromethyl)zinc Reagent

The combination of difluoroiodomethane and zinc dust or diethylzinc can readily lead to (difluoromethyl)zinc reagents. Therefore, the first copper-catalyzed difluoromethylation of aryl iodides with the zinc reagents is accomplished to afford the difluorom