84627-04-3

Basic information

• Product Name: Fendizoic acid
• Synonyms: 2-(6-HYDROXY-BIPHENYL-3-CARBONYL)-BENZOIC ACID;2-[(6-Hydroxy[1,1'-biphenyl]-3-yl)carbonyl]benzoic acid;Fendizoic acid;Levocloperastine IMpurity-Fendizoic Acid;Levocloperastine Fendizoic Acid Impurity;Fedizoic Acid;Bis(Triphenylphosphineiminium Chloride C36H30Clnp2
• CAS NO: 84627-04-3
• Molecular Formula: C₂₀H₁₄O₄
• Molecular Weight: 318.32
• Mol File: 84627-04-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 262-264 °C
• Boiling Point: 593.9 °C at 760 mmHg
• Flash Point: 327 °C
• Appearance: /
• Density: 1.305
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: 3.28±0.36(Predicted)
• CAS DataBase Reference: Fendizoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Fendizoic acid(84627-04-3)
• EPA Substance Registry System: Fendizoic acid(84627-04-3)

Safety Data

• Hazardous Substances Data: 84627-04-3(Hazardous Substances Data)

Usage

Physical Form

Powder

Uses

Fendizoic Acid is a reagent in the synthesis of fluorinated polyphthalazinone ethers containing perfluorophenylene moieties.

Upstream product

• 85-44-9 phthalic anhydride 
• 90-43-7 2-Phenylphenol 

Downstream Products

• 220329-19-1 levocloperastine fendizoate 
• 1623008-16-1 4-(3-phenyl-4-hydroxyphenyl)-2-(pentafluorophenyl)phthalazin-1(2H)-one 
• 84627-12-3 3,3-bis(2-hydroxy-5-biphenylyl)phthalide 
• 84627-11-2 4-(2'-hydroxy-5'-biphenyly)-2-phenyl-1-(1,2-2H)phthalazinone 
• 84627-06-5 3-acetoxy-3-(2'-acetoxy-5'-biphenylyl)phthalide 
• 84627-08-7 2-<(3'-bromo-2'-hydroxy-5'-biphenylyl)carbonyl>benzoic acid 
• 84627-10-1 4-(2'-hydroxy-5'-biphenylyl)-1-(1,2-2H)-phthalazinone 
• 84627-07-6 phenyl 2-hydroxy-5-biphenylyl ketone 
• 18499-78-0 2-hydroxy-3-phenylanthraquinone 
• 84627-09-8 methyl 2-<(3'-bromo-2'-hydroxy-5'-biphenylyl)carbonyl>benzoate 
• 84627-05-4 methyl 2-<(2'-hydroxy-5'-biphenylyl)carbonyl>benzoate 

Relevant articles and documents

Synthesis and characterization of highly fluorinated poly(phthalazinone ether)s based on AB-type monomers

Four different fluorinated methyl- and phenyl-substituted 4-(4-hydroxyphenyl)-2-(pentafluorophenyl)-phthalazin-1(2H)-ones, AB-type phthalazinone monomers, have been successfully synthesized by nucleophilic addition-elimination reactions of methyl- and phenyl-substituted 2-((4-hydroxy)benzoyl)benzoic acid with 1-(pentafluorophenyl)hydrazine. Under mild reaction conditions, the AB-type monomers underwent self-condensation polymerization reactions successfully and gave fluorinated poly(phthalazinone ether)s with high molecular weights. Detailed structural characterization of the AB-type monomers and fluorinated polymers was determined by 1H NMR, 19F NMR, FTIR, and GPC. The solubility, thermal properties, mechanical properties, water contact angles, and optical absorption of the polymers were evaluated. The polymers had high Tgs varying from 337 to 349 °C and decomposition temperatures (Td, 25 wt %) above 409 °C. Tough, flexible films were cast from THF and chloroform solutions. The films showed excellent tensile strengths ranging from 70 to 85 MPa with good hydrophobicities with water contact angles higher than 95.5 °C. The polymers had absorption edges below 340 nm and very low absorbance per cm at higher wavelengths 500-2500 nm. These results indicate that the polymers are promising as high performance materials, for example, membranes and hydrophobic materials.

SYNTHESIS AND REACTIVITY OF 2-AROYLBENZOIC ACIDS. PART I. 2-BENZOIC ACID

Selective Friedel-Crafts 2-carboxybenzoylation of 2-biphenylol with phthalic anhydride led to formation of 2-benzoic acid (1); other isomers were not present.Several chemical methods were involved to investigate reactivity of acid 1.Compound 1 and its derivatives were analyzed with TLC, UV-VIS, IR, 1H NMR and MS methods.