847171-51-1

Basic information

• Product Name: 1-(3-AMINO-4-CHLOROBENZENESULFONYL)-1,2,3,4-TETRAHYDROQUINOLINE
• Synonyms: 1-(3-AMINO-4-CHLOROBENZENESULFONYL)-1,2,3,4-TETRAHYDROQUINOLINE;2-Chloro-5-((3,4-dihydroquinolin-1(2H)-yl)sulfonyl)aniline
• CAS NO: 847171-51-1
• Molecular Formula: C₁₅H₁₅ClN₂O₂S
• Molecular Weight: 322.81
• Mol File: 847171-51-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 507°C at 760 mmHg
• Flash Point: 260.4°C
• Appearance: /
• Density: 1.41g/cm³
• Vapor Pressure: 2.12E-10mmHg at 25°C
• Refractive Index: 1.659
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 1-(3-AMINO-4-CHLOROBENZENESULFONYL)-1,2,3,4-TETRAHYDROQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-AMINO-4-CHLOROBENZENESULFONYL)-1,2,3,4-TETRAHYDROQUINOLINE(847171-51-1)
• EPA Substance Registry System: 1-(3-AMINO-4-CHLOROBENZENESULFONYL)-1,2,3,4-TETRAHYDROQUINOLINE(847171-51-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 847171-51-1(Hazardous Substances Data)

Usage

General Description

1-(3-Amino-4-chlorobenzenesulfonyl)-1,2,3,4-tetrahydroquinoline is a chemical compound with a complex molecular structure, typically used in the field of medicinal chemistry and pharmaceutical research. The presence of several functional groups such as amino, chlorobenzene and sulfonyl contributes to its chemical characteristics and reactivity. It possesses a tetrahydroquinoline backbone, a common moiety in many bioactive molecules. The exact properties and applications of this chemical can vary widely depending on its specific bonding, functional groups and inclusion in larger organic structures. Its usage and role are primarily based on the context of its application within research or industrial settings. Details about its toxicity, potential health impacts, and safety handling measures can be found in the Material Safety Data Sheet (MSDS).

InChI:InChI=1/C15H15ClN2O2S/c16-13-8-7-12(10-14(13)17)21(19,20)18-9-3-5-11-4-1-2-6-15(11)18/h1-2,4,6-8,10H,3,5,9,17H2

Upstream product

• 847170-51-8 1-((4-chloro-3-nitrophenyl)sulfonyl)-1,2,3,4-tetrahydroquinoline 

Relevant articles and documents

NITROGENATED FUSED RING DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE OF THE SAME FOR MEDICAL PURPOSES

[Purpose] The present invention provides compounds useful as agents for the prevention or treatment of a sex hormone-dependent disease or the like. [Solution] The present invention provides nitrogen-containing fused ring derivatives represented by the following general formula (I) which has a GnRH antagonistic activity, prodrugs, salts, pharmaceutical compositions containing the same, medicinal uses thereof and the like. In the formula (I), rings A and B are independently aryl or heteroaryl; RA and RB are independently halogen, cyano, alkyl, alkylsulfonyl, -OW1, -SW1, -COW2, -NW3W4, -SO2NW3W4, aryl, etc.; RC is H or alkyl; E is oxygen atom, etc.; U is single bond or alkylene; and X is Y, -CO-Y, -SO2-Y -S-(alkylene)-Y, -O-(alkylene)-Y, -SO2-(alkylene)-Y, etc.; Y is Z or amino, etc.; and Z is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, etc.

FUSED PYRIMIDINE DERIVATIVE AND USES THEREOF

A compound represented by the formula (I) wherein ring A is a 5-membered aromatic heterocycle optionally having substituent(s), R1 is a hydrogen atom or a hydrocarbon group optionally having substituent(s), W is an oxygen atom or a sulfur atom, X1 and X2 may be the same or different and each is a hydrogen atom, a hydrocarbon group optionally having substituent(s) or a heterocyclic group, or, X1 and X2 in combination optionally form an oxygen atom, a sulfur atom or =NR2, ring B is an aromatic ring optionally further having substituent(s), Y is a bond, C1-6 alkylene C2-6 alkenylene or C2-6 alkynylene, optionally having substituent(s), and Z is a group represented by formula: -SOnR3, or a group represented by formula: -COR4, or a salt thereof, is useful as a pharmaceutical agent having GnRH antagonistic action.