847547-91-5

Basic information

• Product Name: 4-Quinolinecarboxylicacid,2-chloro-3-hydroxy-(9CI)
• Synonyms: 4-Quinolinecarboxylicacid,2-chloro-3-hydroxy-(9CI);4-QUINOLINECARBOXYLIC ACID, 2-CHLORO-3-HYDROXY-;2-Chloro-3-hydroxy-4-quinolinecarboxylic acid;2-chloro-3-hydroxyquinoline-4-carboxylic acid;2-Chloro-3-hydroxyquinoli...
• CAS NO: 847547-91-5
• Molecular Formula: C10H6ClNO3
• Molecular Weight: 223.61254
• Product Categories: QUINOLINE
• Mol File: 847547-91-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 377.566 °C at 760 mmHg
• Flash Point: 182.145 °C
• Appearance: /
• Density: 1.601 g/cm³
• Vapor Pressure: 2.26E-06mmHg at 25°C
• Refractive Index: 1.732
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Quinolinecarboxylicacid,2-chloro-3-hydroxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Quinolinecarboxylicacid,2-chloro-3-hydroxy-(9CI)(847547-91-5)
• EPA Substance Registry System: 4-Quinolinecarboxylicacid,2-chloro-3-hydroxy-(9CI)(847547-91-5)

Safety Data

• Hazardous Substances Data: 847547-91-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H6ClNO3/c11-9-8(13)7(10(14)15)5-3-1-2-4-6(5)12-9/h1-4,13H,(H,14,15)

Upstream product

• 128676-94-8 3-hydroxy-2-chloroquinoline 
• 124-38-9 carbon dioxide 
• 856900-25-9 2-chloro-3-methoxymethoxy-quinoline 
• 612-62-4 2-Chloroquinoline 

Relevant articles and documents

A new approach to 3-hydroxyquinoline-2-carboxylic acid

Quinoline-2-carboxylic acid derivatives cap the N-terminal of several natural cyclic peptides with antitumoral activity. A new and convenient route for the preparation of 3-hydroxyquinoline-2-carboxylic acid is discussed. The preparation of the title compound is accomplished by a four-step procedure from 3-hydroxyquinoline via MOM protection of the hydroxyl group, followed by a 1,2-addition of methyllithium to the quinoline ring with concomitant oxidation, and, finally, a two-step oxidation procedure for the transformation of the methyl group to the carboxylic acid along with removal of the MOM group. Furthermore, different attempts to its preparation led to other interesting quinolines, such as 2-chloro-3-hydroxyquinoline-4-carboxylic acid and a protected 3,3′-dihydroxy-2,2′-biquinoline.