847948-99-6Relevant articles and documents
Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints
Chu, Guo-Hua,Gu, Minghua,Cassel, Joel A.,Belanger, Serge,Graczyk, Thomas M.,Dehaven, Robert N.,Conway-James, Nathalie,Koblish, Mike,Little, Patrick J.,DeHaven-Hudkins, Diane L.,Dolle, Roland E.
, p. 5114 - 5119 (2005)
Two novel chemical classes of kappa opioid receptor agonists, chroman-2-carboxamide derivatives and 2,3-dihydrobenzofuran-2-carboxamide derivatives, were synthesized. These agents exhibited high and selective affinity for the kappa opioid receptor.