847999-52-4Relevant articles and documents
Discovery of a potent and orally bioavailable dual antagonist of CC chemokine receptors 2 and 5
Carter, Percy H.,Brown, Gregory D.,Cherney, Robert J.,Batt, Douglas G.,Chen, Jing,Clark, Cheryl M.,Cvijic, Mary Ellen,Duncia, John V.,Ko, Soo S.,Mandlekar, Sandhya,Mo, Ruowei,Nelson, David J.,Pang, Jian,Rose, Anne V.,Santella, Joseph B.,Tebben, Andrew J.,Traeger, Sarah C.,Xu, Songmei,Zhao, Qihong,Barrish, Joel C.
, p. 439 - 444 (2015/04/27)
We describe the hybridization of our previously reported acyclic and cyclic CC chemokine receptor 2 (CCR2) antagonists to lead to a new series of dual antagonists of CCR2 and CCR5. Installation of a γ-lactam as the spacer group and a quinazoline as a benz
