84812-00-0Relevant articles and documents
Preparation method of antitumor active compound
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, (2017/09/29)
The invention relates to a preparation method of antitumor active compound, belonging to the field of medicinal chemistry. The method comprises the steps of enabling commercialized fully-acetylated glucose serving as a starting raw material and methylene dichloride serving as a solvent to react with 3, 4-dimethoxyphenol under the catalytic action of boron trifluoride ether so as to form a glucose anomeric carbon position-substituted glycoside intermediate; then, removing acetyl under the alkaline condition of sodium methylate, and enabling the product to have a regioselective chemical reaction with benzoyl chloride prepared by using full benzyl-protected anhydrous gallic acid so as to obtain a key glycosyl intermediate; finally, carrying out palladium-carbon reduction to remove benzyl protection. The glycoside natural product 1 is formed in high yield by means of simple and efficient reactions in the four steps; the prepared glycoside natural product has good tumor cytotoxic activity. The structural formula of the glycoside natural product 1 is described in the description.
Studies on the constituents of the bark of Kalopanax pictus Nakai
Sano,Sanada,Ida,Shoji
, p. 865 - 870 (2007/10/02)
Five new compounds, kalopanaxsaponin G (2) and kalopanaxins A (6), B (8), C (11) and D (13), were isolated from the bark of Kalopanax pictus together with nine known compounds, kalopanaxsaponins A (1) and B (5), pericarpsaponin P(J3) (3), hederasaponin B (4), syringin (7), protocatechuic acid (9), coniferin (10), liriodendrin (=dl-syringaresinol di-O-glucopyranoside) (12), glucosyringic acid (14) and chlorogenic acid (15). The structures of the new compounds were characterized as hederagenin 28-O-α-L-rhamnopyranosyl(1→4)-β-D-glucopyranosyl(1→6)-β-D- glucopyranoside (2), ferulylaldehyde (=coniferylaldehyde) 4-O-β-D-glucopyranoside (6), coniferin 6'-O-(4-O-α-L-rhamnopyranosyl)-syringate (8), 2-methoxyhydroquinone 4-O-[6-O[(4-O-α-L-rhamnopyranosyl)-syringyl]-β-D-glucopyranoside (11) and coniferyl alcohol 4-O-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside (=coniferin 2'-O-β-D-apiofuranoside) (13).