848400-44-2

Basic information

• Product Name: N₅-allyl-N₅-(2-chloro-4-methoxyphenyl)-N₇,N₇-dipropylpyrazolo[1,5-a]pyrimidine-5,7-diamine
• Synonyms: N₅-allyl-N₅-(2-chloro-4-methoxyphenyl)-N₇,N₇-dipropylpyrazolo[1,5-a]pyrimidine-5,7-diamine
• CAS NO: 848400-44-2
• Molecular Weight: 413.95
• Mol File: 848400-44-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N₅-allyl-N₅-(2-chloro-4-methoxyphenyl)-N₇,N₇-dipropylpyrazolo[1,5-a]pyrimidine-5,7-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N₅-allyl-N₅-(2-chloro-4-methoxyphenyl)-N₇,N₇-dipropylpyrazolo[1,5-a]pyrimidine-5,7-diamine(848400-44-2)
• EPA Substance Registry System: N₅-allyl-N₅-(2-chloro-4-methoxyphenyl)-N₇,N₇-dipropylpyrazolo[1,5-a]pyrimidine-5,7-diamine(848400-44-2)

Safety Data

• Hazardous Substances Data: 848400-44-2(Hazardous Substances Data)

Upstream product

• 57489-77-7 5,7-dichloropyrazolo[1,5-a]pyrimidine 
• 1338932-02-7 7-N,N-dipropylamino-5-chloro-pyrazolo[1,5-a]pyrimidine 

Relevant articles and documents

Pyrazolo[1,5-a]pyrimidines, triazolo[1,5-a]pyrimidines and their tricyclic derivatives as corticotropin-releasing factor 1 (CRF1) receptor antagonists

To identify structurally novel CRF1 receptor antagonists, a series of bicyclic core antagonists, pyrazolo[1,5-a]pyrimidines, triazolo[1,5-a] pyrimidines, imidazo[1,2-a]pyrimidines and pyrazolo[1,5-a][1,3,5]triazines were designed, synthesized and evaluated as CRF1 receptor antagonists. Compounds 2-27 showed binding affinity (IC50 = 4.2-418 nM) and antagonist activity (EC50 = 4.0-889 nM). Compound 5 was found to show oral efficacy in an Elevated Plus Maze test in rats. Further chemical modification of them led us to discovery of the tricyclic core antagonists pyrazolo[1,5-a]pyrrolo[3,2-e] pyrimidines. The discovery process of these compounds is presented, as is the study of the structure-activity relationship.